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2017-09-01

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/127951

Mediterranean diet and risk of heart failure: results from the PREDIMED randomized controlled trial

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https://doi.org/10.1002/ejhf.750

Abstract

Aims: The aim of this study was to evaluate the effect of the Mediterranean diet (MedDiet) on the incidence of heart failure (HF), a pre-specified secondary outcome in the PREDIMED (PREvencion con DIeta MEDiterrnea) primary nutrition-intervention prevention trial. Methods and results: Participants at high risk of cardiovascular disease were randomly assigned to one of three diets: MedDiet supplemented with extra-virgin olive oil (EVOO), MedDiet supplemented with nuts, or a low-fat control diet. Incident HF was ascertained by a Committee for Adjudication of events blinded to group allocation. Among 7403 participants without prevalent HF followed for a median of 4.8 years, we observed 29 new HF cases in the MedDiet with EVOO group, 33 in the MedDiet with nuts group, and 32 in the control group. No significant association with HF incidence was found for the MedDiet with EVOO and MedDiet with nuts, compared with the control group [hazard ratio (HR) 0.68; 95% confidence interval (CI) 0.41-1.13, and HR 0.92; 95% CI 0.56-1.49, respectively].Conclusion: In this sample of adults at high cardiovascular risk, the MedDiet did not result in lower HF incidence. However, this pre-specified secondary analysis may have been underpowered to provide valid conclusions. Further randomized controlled trials with HF as a primary outcome are needed to better assess the effect of the MedDiet on HF risk.

Subject

Cuina mediterrània, Aturada cardíaca, Malalties del cor

Subject (English)

Mediterranean cooking, Cardiac arrest, Heart diseases

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Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citation

PAPADAKI, Angeliki, et al. Mediterranean diet and risk of heart failure: results from the PREDIMED randomized controlled trial. European Journal of Heart Failure. 2017. Vol. 19, num. 9, pags. 1179-1185. ISSN 1388-9842. [consulted: 9 of June of 2026]. Available at: https://hdl.handle.net/2445/127951

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