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Efficient preparation of (S)- and (R)-tert-Butylmethylphosphine-Borane: a novel entry to important P-Stereogenic ligands
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A novel one-pot reductive methodol. for the synthesis of optically pure tert-butylmethylphosphine-borane is reported. The prepn. uses as the starting material tert-butylmethylphosphinous acid-borane, which is available in both enantiomeric forms from cis-1,2-aminoindanol and tert-butyldichlorophosphine. The process is based on the redn. of a mixed anhydride, the configurational stability of which has been studied in several solvents and temps. Tetrabutylammonium borohydride was the best reducing agent allowing for the development of a practical process. To demonstrate the utility of the new methodol., the product obtained in this manner was used in the prepn. of Quinox-P*.
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SALOMÓ I PRAT, Ernest, ORGUÉ GASSOL, Sílvia, RIERA I ESCALÉ, Antoni, VERDAGUER I ESPAULELLA, Xavier. Efficient preparation of (S)- and (R)-tert-Butylmethylphosphine-Borane: a novel entry to important P-Stereogenic ligands. _Synthesis. Journal of Synthetic Organic Chemistry_. 2016. Vol. 48, núm. 16, pàgs. 2659-2663. [consulta: 23 de gener de 2026]. ISSN: 0039-7881. [Disponible a: https://hdl.handle.net/2445/102067]