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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/215740
Is precision medicine the solution to improve organ preservation in laryngeal/hypopharyngeal cancer? A position paper by the Preserve Research Group
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In locally advanced (LA) laryngeal/hypopharyngeal squamous cell carcinoma (LHSCC), larynx preservation (LP) strategies aim at the cure of the disease while preserving a functional larynx, thus avoiding total laryngectomy and the associated impact on the quality of life. In the last decades, apart from transoral and open-neck organ preservation approaches, several non-surgical regimens have been investigated: radiotherapy alone, alternate, concurrent or sequential chemoradiation, and bioradiotherapy. Despite major progress, the identification of reliable and effective predictors for treatment response remains a clinical challenge. This review examines the current state of LP in LA-LHSCC and the need for predictive factors, highlighting the importance of the PRESERVE trial in addressing this gap. The PRESERVE trial represents a pivotal initiative aimed at finding the optimal therapy for laryngeal preservation specific to each patient through a retrospective analysis of data from previous LP trials and prospectively validating findings. The goal of the PRESERVE trial is to develop a comprehensive predictive classifier that integrates clinical, molecular, and multi-omics data, thereby enhancing the precision and efficacy of patient selection for LP protocols.
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MATTAVELLI, Davide, WICHMANN, Gunnar, SMUSSI, Davide, PADERNO, Alberto, PLANA SERRAHIMA, Maria, MESIA NIN, Ricard, COMPAGNONI, Micaela, MEDDA, Alessandro, CHIOCCA, Susanna, CALZA, Stefano, ZHAN, Yinxiu, ROGNONI, Carla, TARRICONE, Rosanna, STUCCHI, Erika, LORINI, Luigi, GURIZZAN, Cristina, KHELIK, Ksenia, HOVIG, Eivind, DIETZ, Andreas, PIAZZA, Cesare, BOSSI, Paolo. Is precision medicine the solution to improve organ preservation in laryngeal/hypopharyngeal cancer? A position paper by the Preserve Research Group. _Frontiers in Oncology_. 2024. Vol. 14. [consulta: 24 de gener de 2026]. ISSN: 2234-943X. [Disponible a: https://hdl.handle.net/2445/215740]