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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/227420
Molecular dynamics modelling of the interaction of a synthetic zinc-finger miniprotein with DNA
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We report the modelling of the DNA complex of an artificial miniprotein composed of two zinc finger modules and an AT-hook linking peptide. The computational study provides for the first time a structural view of these types of complexes, dissecting interactions that are key to modulate their stability. The relevance of these interactions was validated experimentally. These results confirm the potential of this type of computational approach for studying peptide–DNA complexes and suggest that they could be very useful for the rational design of non-natural, DNA binding miniproteins.
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RODRIGUEZ, Jessica, et al. Molecular dynamics modelling of the interaction of a synthetic zinc-finger miniprotein with DNA. RSC Chemical Biology. 2023. Vol. 4, num. 486-493. [consulted: 19 of August of 2026]. Available at: https://hdl.handle.net/2445/227420