Document type
ArticleVersion
Accepted versionPublication date
All rights reserved
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/118318
Engineered muscle tissues for disease modeling and drug screening applications
Journal Title
Director/Tutor
Journal ISSN
Volume Title
Related resource
Abstract
Animal models have been the main resources for drug discovery and prediction of drugs’ pharmacokinetic responses in the body. However, noticeable drawbacks associated with animal models include high cost, low reproducibility, low physiological similarity to humans, and ethical problems. Engineered tissue models have recently emerged as an alternative or substitute for animal models in drug discovery and testing and disease modeling. In this review, we focus on skeletal muscle and cardiac muscle tissues by first describing their characterization and physiology. Major fabrication technologies (i.e., electrospinning, bioprinting, dielectrophoresis, textile technology, and microfluidics) to make functional muscle tissues are then described. Finally, currently used muscle tissue models in drug screening are reviewed and discussed
Subject
Subject (English)
Citation
Citation
MOHAMMANDI, Mohammad Hossein, et al. Engineered muscle tissues for disease modeling and drug screening applications. Current Pharmaceutical Design. 2017. Vol. 23, num. 2991-3004. ISSN 1381-6128. [consulted: 9 of June of 2026]. Available at: https://hdl.handle.net/2445/118318