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Prospective analysis of circulating metabolites and endometrial.pdf (568.85 KB)

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2021-08-01

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cc by (c) Dossus, Laure et al., 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/179791

Prospective analysis of circulating metabolites and endometrial cancer risk

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Recurs relacionat

https://doi.org/10.1016/j.ygyno.2021.06.001

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Background: Endometrial cancer is strongly associated with obesity and dysregulation of metabolic factors such as estrogen and insulin signaling are causal risk factors for this malignancy. To identify additional novel metabolic pathways associated with endometrial cancer we performed metabolomic analyses on pre-diagnostic plasma samples from 853 case-control pairs from the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: A total of 129 metabolites (acylcarnitines, amino acids, biogenic amines, glycerophospholipids, hexoses, and sphingolipids) were measured by liquid chromatography-mass spectrometry. Conditional logistic regression estimated the associations of metabolites with endometrial cancer risk. An analysis focusing on clusters of metabolites using the bootstrap lasso method was also employed. Results: After adjustment for body mass index, sphingomyelin [SM] C18:0 was positively (OR1SD: 1.18, 95% CI: 1.05-1.33), and glycine, serine, and free carnitine (C0) were inversely (OR1SD: 0.89, 95% CI: 0.80-0.99; OR1SD: 0.89, 95% CI: 0.79-1.00 and OR1SD: 0.91, 95% CI: 0.81-1.00, respectively) associated with endometrial cancer risk. Serine, C0 and two sphingomyelins were selected by the lasso method in >90% of the bootstrap samples. The ratio of esterified to free carnitine (OR1SD: 1.14, 95% CI: 1.02-1.28) and that of short chain to free acylcarnitines (OR1SD: 1.12, 95% CI: 1.00-1.25) were positively associated with endometrial cancer risk. Further adjustment for C-peptide or other endometrial cancer risk factors only minimally altered the results. Conclusion: These findings suggest that variation in levels of glycine, serine, SM C18:0 and free carnitine may represent specific pathways linked to endometrial cancer development. If causal, these pathways may offer novel targets for endometrial cancer prevention.

Matèries

Càncer d'endometri, Obesitat, Trastorns del metabolisme

Matèries (anglès)

Endometrial cancer, Obesity, Disorders of metabolism

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

DOSSUS, Laure, KOULOURA, Eirini, BIESSY, Carine, VIALLON, Vivian, SISKOS, Alexandros p., DIMOU, Niki, RINALDI, Sabina, MERRITT, Melissa a., ALLEN, Naomi e., FORTNER, Renée t., KAAKS, Rudolf, WEIDERPASS, Elisabete, GRAM, Inger t., ROTHWELL, Joseph a., LÉCUYER, Lucie, SEVERI, Gianluca, SCHULZE, Matthias b., NØST, Therese haugdahl, CROUS BOU, Marta, SÁNCHEZ, Maria jose, AMIANO, Pilar, COLORADO-YOHAR, Sandra, BARRICARTE GURREA, Aurelio, SCHMIDT, Julie a., PALLI, Domenico, AGNOLI, Claudia, TUMINO, Rosario, SACERDOTE, Carlotta, MATTIELLO, Amalia, VERMEULEN, Roel, HEATH, Alicia k., CHRISTAKOUDI, Sofia, TSILIDIS, Konstantinos k., TRAVIS, Ruth c., GUNTER, Marc j., KEUN, Hector c.. Prospective analysis of circulating metabolites and endometrial cancer risk. _Gynecologic Oncology_. 2021. Vol. 162, núm. 2, pàgs. 475-481. [consulta: 9 de gener de 2026]. [Disponible a: https://hdl.handle.net/2445/179791]

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