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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/180014
Is Post-Transplant Cyclophosphamide the New Methotrexate?
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Abstract
Introducing post-transplant, cyclophosphamide (PT-Cy) graft-versus-host disease (GVHD) prophylaxis in the setting of haploidentical donor transplantation has marked the most important advance in allogeneic hematopoietic cell transplantation (alloHCT) within the past 15 years. The efficacy of this procedure and its simple features have allowed for the significantly widespread application of alloHCT worldwide. Indeed, the procedure's effectiveness in reducing immunological complications in the haploidentical setting has even challenged the status quo use of calcineurin-inhibitor, methotrexate-based GVHD prophylaxis in the setting of HLA-identical donors. Currently, however, prospective clinical trials in support of PT-Cy-based GVHD prophylaxis in the HLA-matched setting are striving to resolve the matter of its potential role. This review will briefly report the overall outcomes of PT-Cy-based GVHD prophylaxis in the haploidentical setting and summarize results obtained in the HLA-identical field. We will present future perspectives at the end of the manuscript.
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MUSSETTI, Alberto, et al. Is Post-Transplant Cyclophosphamide the New Methotrexate?. Journal of Clinical Medicine. 2021. Vol. 10, num. 16, pags. 3548. ISSN 2077-0383. [consulted: 10 of August of 2026]. Available at: https://hdl.handle.net/2445/180014