Amb motiu del tancament d'estiu, la validació de documents es reprendrà a partir del 28 d'agost de 2026. Disculpeu les molèsties.
Con motivo del cierre de verano, la validación de documentos se reanudará a partir del 28 de agosto de 2026. Disculpad las molestias
Due to the summer closure, document validation will resume starting August 28, 2026. We apologize for any inconvenience.

Stereoselective synthesis of cis-1,3-dimethyltetrahydroisoquinolines: formal synthesis of naphthylisoquinoline alkaloids

Vista senzilla d'ítem
dc.contributor.authorAmat Tusón, Mercedes
dc.contributor.authorSubrizi, Fabiana
dc.contributor.authorElias, Viviane
dc.contributor.authorLlor Brunés, Núria
dc.contributor.authorMolins, Elies
dc.contributor.authorBosch Cartes, Joan
dc.date.accessioned2020-06-04T08:27:34Z
dc.date.available2020-06-04T08:27:34Z
dc.date.issued2012-10
dc.date.updated2020-06-04T08:27:34Z
dc.description.abstractStarting from tricyclic lactam 2, which is easily accessible by cyclocondensation of -oxoester 1 with (R)-phenylglycinol, a three-step synthetic route to enantiopure 1-substituted tetrahydroisoquinolines, including 1-alkyl-, 1-aryl-, and 1-benzyl- tetrahydroisoquinoline alkaloids as well as the tricyclic alkaloid (-)-crispine A, has been developed. The key step is a stereoselective -amidoalkylation reaction using the appropriate Grignard reagent.
dc.format.extent7 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec615888
dc.identifier.issn1434-193X
dc.identifier.urihttps://hdl.handle.net/2445/164259
dc.language.isoeng
dc.publisherWiley-VCH
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1002/ejoc.201200798
dc.relation.ispartofEuropean Journal of Organic Chemistry, 2012, vol. 2012, num. 28, p. 5491-5497
dc.relation.urihttps://doi.org/10.1002/ejoc.201200798
dc.rights(c) Wiley-VCH, 2012
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
dc.subject.classificationSíntesi asimètrica
dc.subject.classificationAlcaloides
dc.subject.classificationLactames
dc.subject.otherAsymmetric synthesis
dc.subject.otherAlkaloids
dc.subject.otherLactams
dc.titleStereoselective synthesis of cis-1,3-dimethyltetrahydroisoquinolines: formal synthesis of naphthylisoquinoline alkaloids
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion

Fitxers

Paquet original

Mostrant 1 - 1 de 1
Miniatura
Nom:
615888.pdf
Mida:
207.68 KB
Format:
Adobe Portable Document Format
Descarregar

Col·leccions

Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
Articles publicats en revistes (Institut de Biomedicina (IBUB))