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draibe2017_3013.pdf (380.68 KB)

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2017-12-02

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cc by-nc (c) Draibe et al., 2017
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/122190

Seasonal variations in the onset of positive and negative renal ANCA-associated vasculitis in Spain

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http://dx.doi.org/10.1093/ckj/sfx127

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Background: The closure of long-standing gaps in our knowledge of aetiological factors behind anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a major challenge. Descriptive and analytical epidemiological studies can improve our understanding of environmental influences. Reported seasonal variations in AAV, mainly related to Wegener's disease, have shown an increasing number of cases in the winter months, which could be related to an extrinsic factor underlying infection. The objective of this paper was to study seasonal variations in AAV with respect to renal affectation diagnosed in Catalonia, Spain. Methods: Two hundred and thirty-four patients diagnosed for renal AAV between 2001 and 2014 in eight hospitals in Catalonia were included in the study. We used medical records to retrospectively analyse the date of the first symptoms attributed to the AAV, ANCA subtypes, the degree of renal impairment and renal histology. Results: Of the 234 patients studied, 49.2% were male and 50.8% female. For ANCA status, 8.5% were positive, 15.9% were proteinase-3-positive and 75.6% were myeloperoxidase-positive. In relation to histological classification, 17.8% were sclerotic, 11.7% focal, 38.8% crescentic and 31.7% mixed. Regarding seasonal distribution, we observed a clear seasonal periodicity with a significantly higher incidence of cases in the winter. Applying an Eigen decomposition, we observed a periodic fluctuation of frequencies around the annual cycle with peaks every 10–12 months, and higher incidence of AAV cases in February. Conclusions: Our results confirm, in Catalonia, the seasonal periodicity of AAV with a higher incidence in the winter, as formerly described in the literature for other regions. An environmental factor, likely one that is infectious, may explain this finding.

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Vasculitis, Epidemiologia

Matèries (anglès)

Vasculitis, Epidemiology

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Articles publicats en revistes (ISGlobal)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

BORDIGNON DRAIBE, Juliana, RODÓ LÓPEZ, Xavier, FULLADOSA, Xavier, MARTINEZ VALENZUELA, Laura, DIAZ ENCARNACIÓN, Montserrat, SANTOS, Lara, MARCO, Helena, QUINTANA PORRAS, Luis f., RODRIGUEZ, Eva, BARROS FREIRÍA, Xoana, GARCIA, Rosa, BALIUS, Anna, CRUZADO, Josep ma., TORRAS AMBRÒS, Joan, Malalties Glomerulars de la Societat Catalana de Nefrologia (GLOMCAT). Seasonal variations in the onset of positive and negative renal
                ANCA-associated vasculitis in Spain. _Clinical Kidney Journal_. 2017. [consulta: 23 de gener de 2026]. ISSN: 2048-8505. [Disponible a: https://hdl.handle.net/2445/122190]

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