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dobano2018_3044.pdf (1.37 MB)

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2018-05-10

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cc by (c) Dobaño et al., 2018
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/122760

High production of pro-inflammatory cytokines by maternal blood mononuclear cells is associated with reduced maternal malaria but increased cord blood infection

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http://dx.doi.org/10.1186/s12936-018-2317-2

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BACKGROUND: Increased susceptibility to malaria during pregnancy is not completely understood. Cellular immune responses mediate both pathology and immunity but the effector responses involved in these processes have not been fully characterized. Maternal and fetal cytokine and chemokine responses to malaria at delivery, and their association with pregnancy and childhood outcomes, were investigated in 174 samples from a mother and child cohort from Mozambique. Peripheral and cord mononuclear cells were stimulated with Plasmodium falciparum lysate and secretion of IL-12p70, IFN-gamma, IL-2, IL-10, IL-8, IL-6, IL-4, IL-5, IL-1beta, TNF, TNF-beta was quantified in culture supernatants by multiplex flow cytometry while cellular mRNA expression of IFN-gamma, TNF, IL-2, IL-4, IL-6, IL-10 and IL-13 was measured by quantitative PCR. RESULTS: Higher concentrations of IL-6 and IL-1beta were associated with a reduced risk of P. falciparum infection in pregnant women (p < 0.049). Pro-inflammatory cytokines IL-6, IL-1beta and TNF strongly correlated among themselves (rho > 0.5, p < 0.001). Higher production of IL-1beta was significantly associated with congenital malaria (p < 0.046) and excessive TNF was associated with peripheral infection and placental lesions (p < 0.044). CONCLUSIONS: Complex network of immuno-pathological cytokine mechanisms in the placental and utero environments showed a potential trade-off between positive and negative effects on mother and newborn susceptibility to infection.

Matèries

Malària, Embaràs

Matèries (anglès)

Malaria, Pregnancy

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Articles publicats en revistes (ISGlobal)
Articles publicats en revistes (Fonaments Clínics)

Citació

DOBAÑO, Carlota, BERTHOUD, Tamara, MANACA, Maria nélia, NHABOMBA, Augusto j., GUINOVART, Caterina, AGUILAR, Ruth, BARBOSA, Arnoldo, GROVES, Penny l., RODRIGUEZ, Mauricio h., JIMÉNEZ, Alfons, QUIMICE, Lazaro m., APONTE, John j., ORDI I MAJÀ, Jaume, DOOLAN, Denise l., MAYOR APARICIO, Alfredo gabriel, ALONSO, Pedro. High production of pro-inflammatory cytokines by maternal blood
                mononuclear cells is associated with reduced maternal malaria
                but increased cord blood infection. _Malaria Journal_. 2018. Vol. 17, núm. 177. [consulta: 9 de gener de 2026]. ISSN: 1475-2875. [Disponible a: https://hdl.handle.net/2445/122760]

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