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2002-02-18

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/225926

Isoprenoid biosynthesis in Escherichia coli via the methylerythritol phosphate pathway: enzymatic conversion of methylerythritol cyclodiphosphate into a phosphorylated derivative of (E)-2-methylbut-2-ene-1,4-diol

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https://doi.org/10.1016/S0040-4039(02)00003-5

Resum

A crude cell-free system from an Escherichia coli strain overexpressing the cluster containing the three genes yfgA, yfgB, and gcpE converted 2-C-methyl-d-erythritol 2,4-cyclodiphosphate (1) into a phosphorylated derivative of (E)-2-methylbut-2-ene-1,4-diol (6), which most probably represents a novel intermediate in the methylerythritol phosphate pathway for isoprenoid biosynthesis. The free diol 6 was accumulated by phosphatase treatment of the crude enzyme preparation and was identified by comparison with a synthetic reference.

Matèries

Escheríchia coli, Enzims microbians

Matèries (anglès)

Escherichia coli, Microbial enzymes

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Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

Citació

SEEMANN, Myriam, et al. Isoprenoid biosynthesis in Escherichia coli via the methylerythritol phosphate pathway: enzymatic conversion of methylerythritol cyclodiphosphate into a phosphorylated derivative of (E)-2-methylbut-2-ene-1,4-diol. Tetrahedron Letters. 2002. Vol. 43, num. 8, pags. 1413-1415. ISSN 0040-4039. [consulted: 25 of May of 2026]. Available at: https://hdl.handle.net/2445/225926

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