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Antibody-Mediated Encephalitis
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Abstract
Antibody-mediated encephalitides constitute a group of inflammatory brain diseases that are characterized by prominent neuropsychiatric symptoms and are associated with antibodies against neuronal
cell-surface proteins, ion channels, or receptors (Table 1).1
Common clinical features include a change in behavior, psychosis, seizures, memory and cognitive
deficits, abnormal movements, dysautonomia, and a decreased level of consciousness. There are, however, no systemic manifestations other than autonomic dysfunction, and this group of diseases is separable from traditional autoimmune
disorders such as systemic lupus erythematosus, which may affect the nervous
system. Also separate from this group of antibody-mediated encephalitides are
several disorders, some of which are paraneoplastic, such as cerebellar degeneration,2
neuromyelitis optica,3
and stiff-person spectrum diseases,4
that are associated with antibodies against neuronal or glial cell-surface antigens but that are
rarely associated with the aforementioned symptoms.
The antibody-mediated encephalitides occur in persons
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DALMAU OBRADOR, Josep and GRAUS RIBAS, Francesc. Antibody-Mediated Encephalitis. New England Journal of Medicine. 2018. Vol. 378, num. 9, pags. 840-851. ISSN 0028-4793. [consulted: 7 of June of 2026]. Available at: https://hdl.handle.net/2445/147222