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2019-05-02

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cc-by (c) Jimenez-Martinez, Emilio et al., 2019
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/166523

Risk factors for surgical site infection after craniotomy: a prospective cohort study

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https://doi.org/10.1186/s13756-019-0525-3

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Background: Although surgical site infection after craniotomy (SSI-CRAN) is a serious complication, risk factors for its development have not been well defined. We aim to identify the risk factors for developing SSI-CRAN in a large prospective cohort of adult patients undergoing craniotomy. Methods: A series of consecutive patients who underwent craniotomy at a university hospital from January 2013 to December 2015 were prospectively assessed. Demographic, epidemiological, surgical, clinical and microbiological data were collected. Patients were followed up in an active post-discharge surveillance programm e for up to one year after surgery. Multivariate analysis was carried out to identify independent risk factors for SSI-CRAN. Results: Among the 595 patients who underwent craniotomy, 91 (15.3%) episodes of SSI-CRAN were recorded, 67 (73.6%) of which were organ/space. Baseline demographic characteristics were similar among patients who developed SSI-CRAN and those who did not. The most frequent causative Gram-positive organisms were Cutibacterium acnes (23.1%) and Staphylococcus epidermidis (23.1%), whereas Enterobacter cloacae (12.1%) was the most commonly isolated Gram-negative agent. In the univariate analysis the factors associated with SSI-CRAN were ASA score > 2 (48.4% vs. 35.5% in SSI-CRAN and no SSI-CRAN respectively, p = 0.025), extrinsic tumour (28.6% vs. 19.2%, p = 0.05), and re-intervention (4.4% vs. 1.4%, p = < 0.001). In the multivariate analysis, ASA score > 2 (AOR: 2.26, 95% CI: 1.32-3.87; p = .003) and re-intervention (OR: 8.93, 95% CI: 5.33-14.96; p < 0.001) were the only factors independently associated with SSI-CRAN. Conclusion: The risk factors and causative agents of SSI-CRAN identified in this study should be considered in the design of preventive strategies aimed to reduce the incidence of this serious complication.

Matèries

Operacions quirúrgiques, Infeccions, Craniometria

Matèries (anglès)

Surgical operations, Infections, Craniometry

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Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

JIMÉNEZ MARTÍNEZ, Emilio, CUERVO REQUENA, Guillermo, HORNERO, Ana, CIERCOLES, Pilar, GABARRÓS, Andreu, CABELLOS MÍNGUEZ, Ma. carmen, PELEGRIN, Ivan, GARCIA SOMOZA, Dolores, ADAMUZ TOMÁS, Jordi, CARRATALÀ, Jordi, PUJOL, Miquel. Risk factors for surgical site infection after craniotomy: a prospective cohort study. _Antimicrobial Resistance and Infection Control_. 2019. Vol. 8, núm. 69. [consulta: 30 de gener de 2026]. ISSN: 2047-2994. [Disponible a: https://hdl.handle.net/2445/166523]

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