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2021

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cc-by (c) van Werkhoven et al., 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/177408

Incidence and predictive biomarkers of Clostridioides difficile infection in hospitalized patients receiving broad-spectrum antibiotics

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https://doi.org/10.1038/s41467-021-22269-y

Resum

Trial enrichment using gut microbiota derived biomarkers by high-risk individuals can improve the feasibility of randomized controlled trials for prevention of Clostridioides difficile infection (CDI). Here, we report in a prospective observational cohort study the incidence of CDI and assess potential clinical characteristics and biomarkers to predict CDI in 1,007 patients ≥ 50 years receiving newly initiated antibiotic treatment with penicillins plus a beta- lactamase inhibitor, 3rd/4th generation cephalosporins, carbapenems, fluoroquinolones or clindamycin from 34 European hospitals. The estimated 90-day cumulative incidences of a first CDI episode is 1.9% (95% CI 1.1-3.0). Carbapenem treatment (Hazard Ratio (95% CI): 5.3 (1.7-16.6)), toxigenic C. difficile rectal carriage (10.3 (3.2-33.1)), high intestinal abundance of Enterococcus spp. relative to Ruminococcus spp. (5.4 (2.1-18.7)), and low Shannon alpha diversity index as determined by 16 S rRNA gene profiling (9.7 (3.2-29.7)), but not nor- malized urinary 3-indoxyl sulfate levels, predicts an increased CDI risk.

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Malalties bacterianes, Antibiòtics, Microbiota

Matèries (anglès)

Bacterial diseases, Antibiotics, Microbiota

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Articles publicats en revistes (Patologia i Terapèutica Experimental)
<b>Publicacions de projectes de recerca finançats per la UE</b>
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

VAN WERKHOVEN, Cornelis h., DUCHER, Annie, BERKELL, Matilda, MYSARA, Mohamed, LAMMENS, Christine, TORRE CISNEROS, Julian, RODRÍGUEZ BAÑO, Jesús, HERGHERA, Delia, CORNELY, Oliver a., BIEHL, Lena m., BERNARD, Louis, DOMÍNGUEZ LUZÓN, Ma. ángeles (maría ángeles), MARAKI, Sofia, BARRAUD, Olivier, NICA, Maria, JAZMATI, Nathalie, SABLIER, Frederique, GUNZBURG, Jean de, MENTRÉ, France, MALHOTRA-KUMAR, Surbhi, BONTEN, Marc j. m., VEHRESCHILD, Maria j. g. t., PUJOL ROJO, Miquel, ANTICIPATE Study Group. Incidence and predictive biomarkers of Clostridioides difficile infection in hospitalized patients receiving broad-spectrum antibiotics. _Nature Communications_. 2021. Vol. 12. [consulta: 24 de gener de 2026]. ISSN: 2041-1723. [Disponible a: https://hdl.handle.net/2445/177408]

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