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2010-02

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cc-by (c) Cervera Álvarez, Álvaro et al., 2010
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/44003

Genetically-defined deficiency of mannose-binding lectin is associated with protection after experimental stroke in mice and outcome in human stroke

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http://dx.doi.org/10.1371/journal.pone.0008433

Abstract

The complement system is a major effector of innate immunity that has been involved in stroke brain damage. Complement activation occurs through the classical, alternative and lectin pathways. The latter is initiated by mannose-binding lectin (MBL) and MBL-associated serine proteases (MASPs). Here we investigated whether the lectin pathway contributes to stroke outcome in mice and humans.

Subject

Enzims proteolítics, Infart cerebral, Immunitat, Models animals en la investigació

Subject (English)

Proteolytic enzymes, Cerebral infarctio, Immunity, Animal models in research

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Articles publicats en revistes (Biomedicina)

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CERVERA ÁLVAREZ, Álvaro, et al. Genetically-defined deficiency of mannose-binding lectin is associated with protection after experimental stroke in mice and outcome in human stroke. PLoS One. 2010. Vol. 5, num. 2, pags. e8433. ISSN 1932-6203. [consulted: 12 of June of 2026]. Available at: https://hdl.handle.net/2445/44003

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