Genetically-defined deficiency of mannose-binding lectin is associated with protection after experimental stroke in mice and outcome in human stroke

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dc.contributor.authorCervera Álvarez, Álvaro
dc.contributor.authorPlanas Obradors, Anna Maria
dc.contributor.authorJusticia Mercader, Carles
dc.contributor.authorUrra, Xabier
dc.contributor.authorJensenius, Jens C.
dc.contributor.authorTorres Peraza, Jesús Fernando
dc.contributor.authorLozano Soto, Francisco
dc.contributor.authorChamorro Sánchez, Ángel
dc.date.accessioned2013-06-03T16:35:11Z
dc.date.available2013-06-03T16:35:11Z
dc.date.issued2010-02
dc.date.updated2013-06-03T16:35:11Z
dc.description.abstractThe complement system is a major effector of innate immunity that has been involved in stroke brain damage. Complement activation occurs through the classical, alternative and lectin pathways. The latter is initiated by mannose-binding lectin (MBL) and MBL-associated serine proteases (MASPs). Here we investigated whether the lectin pathway contributes to stroke outcome in mice and humans.
dc.format.extent10 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec598553
dc.identifier.issn1932-6203
dc.identifier.pmid20140243
dc.identifier.urihttps://hdl.handle.net/2445/44003
dc.language.isoeng
dc.publisherPublic Library of Science (PLoS)
dc.relation.isformatofReproducció del document publicat a: 10.1371/journal.pone.0008433
dc.relation.ispartofPLoS One, 2010, vol. 5, num. 2, p. e8433
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/201024/EU//ARISE
dc.relation.urihttp://dx.doi.org/10.1371/journal.pone.0008433
dc.rightscc-by (c) Cervera Álvarez, Álvaro et al., 2010
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es
dc.sourceArticles publicats en revistes (Biomedicina)
dc.subject.classificationEnzims proteolítics
dc.subject.classificationInfart cerebral
dc.subject.classificationImmunitat
dc.subject.classificationModels animals en la investigació
dc.subject.otherProteolytic enzymes
dc.subject.otherCerebral infarctio
dc.subject.otherImmunity
dc.subject.otherAnimal models in research
dc.titleGenetically-defined deficiency of mannose-binding lectin is associated with protection after experimental stroke in mice and outcome in human stroke
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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