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Cancer Medicine 2023 Carpio Differences in glucose metabolic activity in liver metastasis separates two groups of 2.pdf (759.01 KB)

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2023-07-01

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cc-by (c) Del Carpio Huerta, et al. 2023
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/231477

Differences in glucose metabolic activity in liver metastasis separates two groups of metastatic uveal melanoma patients with different prognosis

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https://doi.org/10.1002/cam4.6058

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Background: Uveal melanoma metastasizes to the liver. We aimed to explore the metabolic activity of liver metastases (LM) as a biomarker for survival.Methods: We analyzed newly diagnosed patients with metastatic UM (MUM) with LM detected by liver-directed imaging and had undergone a PET/CT at diagnosis.Findings: 51 patients were identified between 2004 and 2019. Median age was 62 years, 41% male and 22% ECOG =1. LDH, ALP, and GGT were elevated in 49%, 37%, and 57% of patients. Median LM SUVmax was 8.5 (3-42.2). Same size lesions presented a wide range of metabolic activity. Median OS was 17.3 m (95% CI:10.6-23.9). Patients with SUVmax = 8.5 had an OS of 9.4 m (95% CI:6.4-12.3), whereas patients with SUVmax <8.5 had an OS of 38.4 m (95% CI:21.4-55.5; p < 0.0001, HR = 2.9). We observed similar results when studying M1a disease separately. Multivariate analysis showed SUVmax as an independent prognostic factor for the whole population and those with M1a disease.Interpretation:Increased metabolic activity of LM seems to be an independent predictor of survival. MUM is a heterogeneous disease and metabolic activity probably reflects a different intrinsic behavior.

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DEL CARPIO HUERTA, Luis Paul, et al. Differences in glucose metabolic activity in liver metastasis separates two groups of metastatic uveal melanoma patients with different prognosis. del Carpio. LP;Algarra. Vol. MA;Sabaté Llobera, num. A;Rodriguez Vida, pags. A;Rossi Seoane. ISSN 2045-7634. [consulted: 19 of September of 2026]. Available at: https://hdl.handle.net/2445/231477

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