Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Tots els drets reservats
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/51724
Insulin dysfunction and allostic load in bipolar disorder
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Bipolar disorder (BD) is associated with substantial morbidity, as well as premature mortality. Available evidence indicates that 'stress-sensitive' chronic medical disorders, such as cardiovascular disease, obesity and Type 2 diabetes mellitus, are critical mediators and/or moderators of BD. Changes in physiologic systems implicated in allostasis have been proposed to impact brain structures and neurocognition, as well as medical comorbidity in this population. For example, abnormalities in insulin physiology, for example, insulin resistance, hyperinsulinemia and central insulinopenia, are implicated as effectors of allostatic load in BD. Insulin's critical role in CNS physiological (e.g., neurotrophism and synaptic plasticity) and pathophysiological (e.g., neurocognitive deficits, pro-apoptosis and amyloid deposition) processes is amply documented. This article introduces the concept that insulin is a mediator of allostatic load in the BD and possibly a therapeutic target.
Matèries
Matèries (anglès)
Citació
Citació
BRIETZKE, Elisa, KAPCZINSKI, Flávio, GRASSI-OLIVEIRA, Rodrigo, GRANDE I FULLANA, Iria, VIETA I PASCUAL, Eduard, MCINTYRE, Roger s.. Insulin dysfunction and allostic load in bipolar disorder. _Expert Review of Neurotherapeutics_. 2011. Vol. 11, núm. 7, pàgs. 1017-1028. [consulta: 10 de gener de 2026]. ISSN: 1473-7175. [Disponible a: https://hdl.handle.net/2445/51724]