Stereoselective syntheses of the antihistaminic drug olopatadine and its E-isomer

Vista senzilla d'ítem
dc.contributor.authorBosch Cartes, Joan
dc.contributor.authorBachs, Jordi
dc.contributor.authorGómez, Antonia M.
dc.contributor.authorGriera Farres, Rosa
dc.contributor.authorÉcija, Marta
dc.contributor.authorAmat Tusón, Mercedes
dc.date.accessioned2017-03-03T15:44:50Z
dc.date.available2017-03-03T15:44:50Z
dc.date.issued2012-07-20
dc.date.updated2017-03-03T15:44:50Z
dc.description.abstractPractical stereoselective synthetic routes to the antihistaminic drug olopatadine and its E-isomer have been developed, the key steps being a trans stereoselective Wittig olefination using a nonstabilized phosphorus ylide and a stereoselective Heck cyclization. The stereoselectivity of the Wittig reaction depends on both the phosphonium salt anion and the cation present in the base used to generate the ylide.
dc.format.extent5 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec615886
dc.identifier.issn0022-3263
dc.identifier.urihttps://hdl.handle.net/2445/107829
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1021/jo300925c
dc.relation.ispartofJournal of Organic Chemistry, 2012, vol. 77, num. 14, p. 6340-6344
dc.relation.urihttps://doi.org/10.1021/jo300925c
dc.rights(c) American Chemical Society , 2012
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
dc.subject.classificationAntihistamínics
dc.subject.classificationEstructura molecular
dc.subject.classificationSíntesi orgànica
dc.subject.otherAntihistamines
dc.subject.otherMolecular structure
dc.subject.otherOrganic synthesis
dc.titleStereoselective syntheses of the antihistaminic drug olopatadine and its E-isomer
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion

Fitxers

Paquet original

Mostrant 1 - 1 de 1
Miniatura
Nom:
615886.pdf
Mida:
266.49 KB
Format:
Adobe Portable Document Format
Descarregar

Col·leccions

Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)