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Article

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Published version

Publication date

2018-03-25

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cc-by (c) Ràfols Llach, Clara et al., 2018
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/143444

Dissolution rates of ciprofloxacin and its cocrystal with resorcinol

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https://doi.org/10.5599/admet.6.1.497

Abstract

The synthesis of cocrystals is presented as an alternative to improve the properties of active pharmaceutical ingredients, especially those related to solubility and dissolution rate. In this work the dissolution rate of ciprofloxacin, a zwitterionic fluoroquinolone antibiotic, has been compared to its cocrystal with resorcinol. To this end, dissolution rate has been determined at several biorelevant pH values, and also in two simulated gastrointestinal fluids (FeSSIF and FaSSIF). Results show that both, ciprofloxacin and the cocrystal, dissolve more slowly as pH increases (from 2.0 to 7.4), as ionization degree of ciprofloxacin decreases. In addition, dissolution is not enhanced by the components of the gastrointestinal fluids

Subject

Sals, Àcids

Subject (English)

Salts, Acids

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Articles publicats en revistes (Enginyeria Química i Química Analítica)

Citation

RÀFOLS LLACH, Clara, et al. Dissolution rates of ciprofloxacin and its cocrystal with resorcinol. ADMET & DMPK. 2018. Vol. 6, num. 1, pags. 61-70. ISSN 1848-7718. [consulted: 9 of June of 2026]. Available at: https://hdl.handle.net/2445/143444

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