Dissolution rates of ciprofloxacin and its cocrystal with resorcinol

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dc.contributor.authorRàfols Llach, Clara
dc.contributor.authorFael, Hanan
dc.contributor.authorFuguet i Jordà, Elisabet
dc.contributor.authorOuthwaite, Breeze
dc.contributor.authorLee, Samuel
dc.contributor.authorRuiz, Rebeca
dc.date.accessioned2019-10-29T13:02:08Z
dc.date.available2019-10-29T13:02:08Z
dc.date.issued2018-03-25
dc.date.updated2019-10-29T13:02:08Z
dc.description.abstractThe synthesis of cocrystals is presented as an alternative to improve the properties of active pharmaceutical ingredients, especially those related to solubility and dissolution rate. In this work the dissolution rate of ciprofloxacin, a zwitterionic fluoroquinolone antibiotic, has been compared to its cocrystal with resorcinol. To this end, dissolution rate has been determined at several biorelevant pH values, and also in two simulated gastrointestinal fluids (FeSSIF and FaSSIF). Results show that both, ciprofloxacin and the cocrystal, dissolve more slowly as pH increases (from 2.0 to 7.4), as ionization degree of ciprofloxacin decreases. In addition, dissolution is not enhanced by the components of the gastrointestinal fluids
dc.format.extent10 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec680469
dc.identifier.issn1848-7718
dc.identifier.urihttps://hdl.handle.net/2445/143444
dc.language.isoeng
dc.publisherIAPC Publishing
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.5599/admet.6.1.497
dc.relation.ispartofADMET & DMPK, 2018, vol. 6 , num. 1, p. 61-70
dc.relation.urihttps://doi.org/10.5599/admet.6.1.497
dc.rightscc-by (c) Ràfols Llach, Clara et al., 2018
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es
dc.sourceArticles publicats en revistes (Enginyeria Química i Química Analítica)
dc.subject.classificationSals
dc.subject.classificationÀcids
dc.subject.otherSalts
dc.subject.otherAcids
dc.titleDissolution rates of ciprofloxacin and its cocrystal with resorcinol
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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