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2025-01-28

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cc by-nc-nd (c) Moreso, Francesc et al., 2025
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/221932

Development and validation of the Neuro-Score: a specific scale to detect and monitor cognitive impairment in kidney or liver transplant recipients

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Recurs relacionat

https://doi.org/10.1016/j.ajt.2025.01.031

Resum

We created and validated the Neuro-Score, a specific scale to detect and monitor cognitive impairment, including mild stages, in kidney or liver transplant recipients. A qualitative study was conducted to define a preliminary set of 62 items. Item reduction was performed using exploratory factor analysis. Confirmatory factor analysis assessed the adequacy of the factorial solution. The total scores of the Neuro-Score and mini-mental state examination were compared. Responsiveness to change was evaluated from visit 1 (baseline) to 2A (18 months later) and temporal stability from visit 2A to 2B (1-2 weeks later). Factor analysis showed 11 factors with an eigenvalue of >1. Confirmatory factor analysis yielded a logical solution with 1 factor and 11 items that explained 27.9% of the variance. The final model showed satisfactory internal consistency (Cronbach alpha- 0.82). A weak negative correlation was found between Neuro-Score and mini-mental state examination total scores (Pearson r--0.12; P-.0095). The Neuro-Score responsiveness to change was demonstrated (P-.022). No significant differences in the total score were observed between visits 2A and 2B, supporting the Neuro-Score temporal stability. The Neuro-Score scale is a simple, reliable, self-administered, easy-to-interpret, and consistent 11-item scale to detect and monitor cognitive impairment in kidney and liver transplant recipients.

Matèries

Trastorns de la cognició, Trasplantament renal, Trasplantament hepàtic

Matèries (anglès)

Cognition disorders, Kidney transplantation

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

MORESO, Francesc, et al. Development and validation of the Neuro-Score: a specific scale to detect and monitor cognitive impairment in kidney or liver transplant recipients. American Journal of Transplantation. 2025. Vol. 25, num. 5, pags. 1059-1069. ISSN 1600-6143. [consulted: 13 of July of 2026]. Available at: https://hdl.handle.net/2445/221932

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