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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/221932
Development and validation of the Neuro-Score: a specific scale to detect and monitor cognitive impairment in kidney or liver transplant recipients
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We created and validated the Neuro-Score, a specific scale to detect and monitor cognitive impairment, including mild stages, in kidney or liver transplant recipients. A qualitative study was conducted to define a preliminary set of 62 items. Item reduction was performed using exploratory factor analysis. Confirmatory factor analysis assessed the adequacy of the factorial solution. The total scores of the Neuro-Score and mini-mental state examination were compared. Responsiveness to change was evaluated from visit 1 (baseline) to 2A (18 months later) and temporal stability from visit 2A to 2B (1-2 weeks later). Factor analysis showed 11 factors with an eigenvalue of >1. Confirmatory factor analysis yielded a logical solution with 1 factor and 11 items that explained 27.9% of the variance. The final model showed satisfactory internal consistency (Cronbach alpha- 0.82). A weak negative correlation was found between Neuro-Score and mini-mental state examination total scores (Pearson r--0.12; P-.0095). The Neuro-Score responsiveness to change was demonstrated (P-.022). No significant differences in the total score were observed between visits 2A and 2B, supporting the Neuro-Score temporal stability. The Neuro-Score scale is a simple, reliable, self-administered, easy-to-interpret, and consistent 11-item scale to detect and monitor cognitive impairment in kidney and liver transplant recipients.
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MORESO, Francesc, et al. Development and validation of the Neuro-Score: a specific scale to detect and monitor cognitive impairment in kidney or liver transplant recipients. American Journal of Transplantation. 2025. Vol. 25, num. 5, pags. 1059-1069. ISSN 1600-6143. [consulted: 17 of October of 2026]. Available at: https://hdl.handle.net/2445/221932