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2019-05-14

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/162398

Exploring the Molecular Pathways Behind the Effects of Nutrients and Dietary Polyphenols on Gut Microbiota and Intestinal Permeability: A Perspective on the Potential of Metabolomics and Future Clinical Applications.

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Recurs relacionat

https://doi.org/10.1021/acs.jafc.9b01687

Resum

The gut microbiota is involved in the regulation of the intestinal permeability (IP), whose disruption is a frequent condition in older people and is associated with the development of several diseases. The diet can affect the gut microbiota and IP, although the molecular mechanisms involved are unclear. Metabolomics is one of the suitable approaches to study the effects of diet on gut microbiota and IP, although, up to now, the research has focused only on a few dietary components. The aim here was to review the most recent literature concerning the application of metabolomics to the study of the diet-induced alterations of gut microbiota and the effects on IP, with a particular focus on the molecular pathways involved. An additional aim was to give a perspective on the future research involving dietary polyphenols, because despite their potential use in the management of increased IP, few studies have been reported to date.

Matèries

Microbiologia, Microbiota intestinal, Metabolisme, Polifenols, Metabolòmica, Envelliment, Mucosa gastrointestinal

Matèries (anglès)

Microbiology, Gastrointestinal microbiome, Metabolism, Polyphenols, Metabolomics, Aging, Gastrointestinal mucosa

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Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
Articles publicats en revistes (Institut de Recerca en Nutrició i Seguretat Alimentària (INSA·UB))

Citació

PERON, Gregorio, et al. Exploring the Molecular Pathways Behind the Effects of Nutrients and Dietary Polyphenols on Gut Microbiota and Intestinal Permeability: A Perspective on the Potential of Metabolomics and Future Clinical Applications. Journal of Agricultural and Food Chemistry. 2019. Vol. 68, num. 7, pags. 1780-1789. ISSN 0021-8561. [consulted: 29 of May of 2026]. Available at: https://hdl.handle.net/2445/162398

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