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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/222217
The exposome and pancreatic cancer, lifestyle and environmental risk factors for PDAC
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Pancreatic cancer (PC), particularly pancreatic ductal adenocarcinoma (PDAC), is a significant global health issue with high mortality rates. PDAC, though only 3 % of cancer diagnoses, causes 7 % of cancer deaths due to its severity and asymptomatic early stages. Risk factors include lifestyle choices, environmental exposures, and genetic predispositions. Conditions like new-onset type 2 diabetes and chronic pancreatitis also contribute significantly. Modifiable risk factors include smoking, alcohol consumption, non-alcoholic fatty pancreatic disease (NAFPD), and obesity. Smoking and heavy alcohol consumption increase PC risk, while NAFPD and obesity, particularly central adiposity, contribute through chronic inflammation and insulin resistance. Refined sugar and sugar-sweetened beverages (SSBs) are also linked to increased PC risk, especially among younger individuals. Hormonal treatments and medications like statins, aspirin, and metformin have mixed results on PC risk, with some showing protective effects. The gut microbiome influences PC through the gut-pancreas axis, with disruptions leading to inflammation and carcinogenesis. Exposure to toxic substances, including heavy metals and chemicals, is associated with increased PC risk. Glycome changes, such as abnormal glycosylation patterns, are significant in PDAC development and offer potential for early diagnosis. Interactions between environmental and genetic factors are crucial in PDAC susceptibility. Genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) linked to PDAC, but gene-environment interactions remain largely unexplored. Future research should focus on polygenic risk scores (PRS) and large-scale studies to better understand these interactions and their impact on PDAC risk.
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PEDUZZI, Giulia, ARCHIBUGI, Livia, FARINELLA, Riccardo, LEON PISANI, Ruggero ponz de, VODIČKOVÁ, Ludmila, VODIČKA, Pavel, KRAJA, Bledar, SAINZ PÉREZ, Juan, BARS CORTINA, David, DANIEL, Neil, SILVESTRI, Roberto, UYSAL ONGANER, Pinar, LANDI, Stefano, DULIŃSKA LITEWKA, Joanna, COMANDATORE, Annalisa, CAMPA, Daniele, HUGHES, David j., RIZZATO, Cosmeri. The exposome and pancreatic cancer, lifestyle and environmental risk factors for PDAC. _Seminars in Cancer Biology_. 2025. Vol. 113, núm. 100-129. [consulta: 14 de gener de 2026]. ISSN: 1044-579X. [Disponible a: https://hdl.handle.net/2445/222217]