Amb motiu del tancament d'estiu, la validació de documents es reprendrà a partir del 28 d'agost de 2026. Disculpeu les molèsties.
Con motivo del cierre de verano, la validación de documentos se reanudará a partir del 28 de agosto de 2026. Disculpad las molestias
Due to the summer closure, document validation will resume starting August 28, 2026. We apologize for any inconvenience.

Files

1-s2.0-S1044579X25000616-main.pdf (2.39 MB)

Document type

Article

Version

Published version

Publication date

2025-05-12

Publication license

cc-by-nc-nd (c) Peduzzi, Giulia et al., 2025
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/222217

The exposome and pancreatic cancer, lifestyle and environmental risk factors for PDAC

Journal Title

Authors

Director/Tutor

Journal ISSN

Volume Title

Related resource

https://doi.org/10.1016/j.semcancer.2025.05.004

Abstract

Pancreatic cancer (PC), particularly pancreatic ductal adenocarcinoma (PDAC), is a significant global health issue with high mortality rates. PDAC, though only 3 % of cancer diagnoses, causes 7 % of cancer deaths due to its severity and asymptomatic early stages. Risk factors include lifestyle choices, environmental exposures, and genetic predispositions. Conditions like new-onset type 2 diabetes and chronic pancreatitis also contribute significantly. Modifiable risk factors include smoking, alcohol consumption, non-alcoholic fatty pancreatic disease (NAFPD), and obesity. Smoking and heavy alcohol consumption increase PC risk, while NAFPD and obesity, particularly central adiposity, contribute through chronic inflammation and insulin resistance. Refined sugar and sugar-sweetened beverages (SSBs) are also linked to increased PC risk, especially among younger individuals. Hormonal treatments and medications like statins, aspirin, and metformin have mixed results on PC risk, with some showing protective effects. The gut microbiome influences PC through the gut-pancreas axis, with disruptions leading to inflammation and carcinogenesis. Exposure to toxic substances, including heavy metals and chemicals, is associated with increased PC risk. Glycome changes, such as abnormal glycosylation patterns, are significant in PDAC development and offer potential for early diagnosis. Interactions between environmental and genetic factors are crucial in PDAC susceptibility. Genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) linked to PDAC, but gene-environment interactions remain largely unexplored. Future research should focus on polygenic risk scores (PRS) and large-scale studies to better understand these interactions and their impact on PDAC risk.

Subject

Càncer de pàncrees, Factors de risc en les malalties, Avaluació del risc per la salut

Subject (English)

Pancreas cancer, Risk factors in diseases, Health risk assessment

Citation

Collections

Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citation

PEDUZZI, Giulia, et al. The exposome and pancreatic cancer, lifestyle and environmental risk factors for PDAC. Seminars in Cancer Biology. 2025. Vol. 113, num. 100-129. ISSN 1044-579X. [consulted: 8 of August of 2026]. Available at: https://hdl.handle.net/2445/222217

Export metadata

JSON - METS

Share record