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2020-07-31

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/171648

Incidence of co-infections and superinfections in hospitalised patients with COVID-19: a retrospective cohort study

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https://doi.org/10.1016/j.cmi.2020.07.041

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Objectives: To describe the burden, epidemiology and outcomes of co-infections and superinfections occurring in hospitalized patients with coronavirus disease 2019 (COVID-19). Methods: We performed an observational cohort study of all consecutive patients admitted for ≥48 hours to the Hospital Clinic of Barcelona for COVID-19 (28 February to 22 April 2020) who were discharged or dead. We describe demographic, epidemiologic, laboratory and microbiologic results, as well as outcome data retrieved from electronic health records. Results: Of a total of 989 consecutive patients with COVID-19, 72 (7.2%) had 88 other microbiologically confirmed infections: 74 were bacterial, seven fungal and seven viral. Community-acquired co-infection at COVID-19 diagnosis was uncommon (31/989, 3.1%) and mainly caused by Streptococcus pneumoniae and Staphylococcus aureus. A total of 51 hospital-acquired bacterial superinfections, mostly caused by Pseudomonas aeruginosa and Escherichia coli, were diagnosed in 43 patients (4.7%), with a mean (SD) time from hospital admission to superinfection diagnosis of 10.6 (6.6) days. Overall mortality was 9.8% (97/989). Patients with community-acquired co-infections and hospital-acquired superinfections had worse outcomes. Conclusions: Co-infection at COVID-19 diagnosis is uncommon. Few patients developed superinfections during hospitalization. These findings are different compared to those of other viral pandemics. As it relates to hospitalized patients with COVID-19, such findings could prove essential in defining the role of empiric antimicrobial therapy or stewardship strategies.

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COVID-19, Infeccions

Matèries (anglès)

COVID-19, Infections

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Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (ISGlobal)

Citació

GARCIA VIDAL, Carolina, SANJUAN, Gemma, MORENO GARCÍA, Estela, PUERTA-ALCALDE, Pedro, GARCIA-POUTON, Nicole, CHUMBITA, Mariana, FERNÁNDEZ PITTOL, Mariana josé, PITART, Cristina, INCIARTE PORTILLO, Alexy, BODRO, Marta, MORATA, Laura, AMBROSIONI, Juan, GRAFIA, Ignacio, MEIRA, Fernanda, MACAYA, Irene, CARDOZO ESPINOLA, Celia, CASALS PASCUAL, Climent, TELLEZ, Adrian, CASTRO REBOLLO, Pedro, MARCO REVERTÉ, Francesc, GARCÍA ALCAIDE, Felipe, MENSA PUEYO, Josep, MARTÍNEZ, José antonio (martínez martínez), SORIANO VILADOMIU, Alex, COVID-19 Researchers Group. Incidence of co-infections and superinfections in hospitalised patients with COVID-19: a retrospective cohort study. _Clinical Microbiology and Infection_. 2020. Vol. S1198-743X. [consulta: 23 de gener de 2026]. ISSN: 1198-743X. [Disponible a: https://hdl.handle.net/2445/171648]

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