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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/118640
ApoA-I Mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer.
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Low levels of high-density lipoprotein cholesterol (HDLc) have been associated with breast cancer risk, but several epidemiologic studies have reported contradictory results with regard to the relationship between apolipoprotein (apo) A-I and breast cancer. We aimed to determine the effects of human apoA-I overexpression and administration of specific apoA-I mimetic peptide (D-4F) on tumour progression by using mammary tumour virus-polyoma middle T-antigen transgenic (PyMT) mice as a model of inherited breast cancer. Expression of human apoA-I in the mice did not affect tumour onset and growth in PyMT transgenic mice, despite an increase in the HDLc level. In contrast, D-4F treatment significantly increased tumour latency and inhibited the development of tumours. The effects of D-4F on tumour development were independent of 27-hydroxycholesterol. However, D-4F treatment reduced the plasma oxidized low-density lipoprotein (oxLDL) levels in mice and prevented oxLDL-mediated proliferative response in human breast adenocarcinoma MCF-7 cells. In conclusion, our study shows that D-4F, but not apoA-I-containing HDL, hinders tumour growth in mice with inherited breast cancer in association with a higher protection against LDL oxidative modification
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CEDÓ GINÉ, Lídia, GARCÍA LEÓN, Annabel, BAILA RUEDA, Lucía, SANTOS, David, GRIJALVA, Victor, MARTÍNEZ CIGNONI, Melanie raquel, CARBÓ, José m., METSO, Jari, LÓPEZ VILARÓ, Laura, ZORZANO OLARTE, Antonio, VALLEDOR FERNÁNDEZ, Annabel, CENARRO, Ana, JAUHIAINEN, Matti, LERMA, Enrique, FOGELMAN, Alan m., REDDY, Srinivasa t., ESCOLÀ GIL, Joan carles, BLANCO-VACA, Francisco. ApoA-I Mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer.. _Scientific Reports_. 2016. Vol. 6, núm. 36387. [consulta: 24 de gener de 2026]. ISSN: 2045-2322. [Disponible a: https://hdl.handle.net/2445/118640]