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Article

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Accepted version

Publication date

2013-03-07

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/36425

Enantioselective formal synthesis of ent-rhynchophylline and ent-isorhynchophylline

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http://dx.doi.org/10.1039/c2cc38540f

Abstract

Starting from (S)-tryptophanol, a formal synthesis of ent-rhyncho-phylline and ent-isorhynchophylline, involving stereoselective cyclocondensation, spirocyclization, and alkylation reactions, and the final adjustment of the oxidation level at the oxindole and piperidine moieties, is reported.

Subject

Alcaloides, Síntesi asimètrica, Estereoquímica

Subject (English)

Alkaloids, Asymmetric synthesis, Stereochemistry

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Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

Citation

AMAT TUSÓN, Mercedes, et al. Enantioselective formal synthesis of ent-rhynchophylline and ent-isorhynchophylline. Chemical Communications. 2013. Vol. 49, num. 19, pags. 1954-1956. ISSN 1359-7345. [consulted: 14 of August of 2026]. Available at: https://hdl.handle.net/2445/36425

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