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jcdd-09-00439-v2.pdf (946.81 KB)

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2022-12-06

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cc by (c) Martínez Solano, Jorge et al., 2022
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/193105

Pulmonary Vascular Remodeling and Prognosis in Patients Evaluated for Heart Transplantation: Insights from the OCTOPUS-CHF Study

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https://doi.org/10.3390/jcdd9120439

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Objective: In patients with advanced heart failure, the intravascular optical coherence tomography (OCT) of subsegmental pulmonary artery measurements is correlated with right heart catheterization parameters. Our aim was to study the prognostic value of pulmonary OCT, right heart catheterization data, and the echocardiographic estimation of pulmonary pressure in patients studied for elective heart transplants. Methods: This research is an observational, prospective, multicenter study involving 90 adults with a one-year follow-up. Results: A total of 10 patients (11.1%) died due to worsening heart failure before heart transplantation, 50 underwent a heart transplant (55.6%), and 9 died in the first year after the transplant. The patients with and without events (mortality or heart failure-induced hospitalization) had similar data regarding echocardiography, right heart catheterization, and pulmonary OCT (with a median estimated pulmonary artery systolic pressure of 42.0 mmHg, interquartile range (IQR) of 30.3-50.0 vs. 47.0 mmHg, IQR 34.6-59.5 and p = 0.79, median pulmonary vascular resistance of 2.2 Wood units, IQR 1.3-3.7 vs. 2.0 Wood units, IQR 1.4-3.2 and p = 0.99, and a median pulmonary artery wall thickness of 0.2 +/- 0.5 mm vs. 0.2 +/- 0.6 mm and p = 0.87). Conclusion: Pulmonary vascular remodeling (evaluated with echocardiography, right heart catheterization, and pulmonary OCT) was not associated with prognosis in a selected sample of adults evaluated for elective heart transplants. Pulmonary OCT is safe and feasible for the evaluation of these patients.

Matèries

Trasplantament cardíac, Hipertensió pulmonar, Pronòstic mèdic

Matèries (anglès)

Heart transplantation, Pulmonary hypertension, Prognosis

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

MARTÍNEZ SOLANO, Jorge, GUTIÉRREZ IBAÑES, Enrique, ORTIZ BAUTISTA, Carlos, GARCÍA COSÍO, María dolores, SARNAGO CEBADA, Fernando, DÍAZ MOLINA, Beatriz, PASCUAL, Isaac, OTEO DOMÍNGUEZ, Juan francisco, GÓMEZ BUENO, Manuel, CALVIÑO SANTOS, Ramón, CRESPO LEIRO, María g., GÓMEZ HOSPITAL, Joan antoni, DÍEZ LÓPEZ, Carles, GARCÍA LARA, Juan, GARRIDO BRAVO, Iris, FUENTE GALÁN, Luis de la, LÓPEZ DÍAZ, Javier, MIRABET PÉREZ, Sonia, MARTÍNEZ SELLÉS, Manuel. Pulmonary Vascular Remodeling and Prognosis in Patients Evaluated for Heart Transplantation: Insights from the OCTOPUS-CHF Study. _Journal of Cardiovascular Development and Disease_. 2022. Vol. 9, núm. 12, pàgs. 439. [consulta: 8 de gener de 2026]. ISSN: 2308-3425. [Disponible a: https://hdl.handle.net/2445/193105]

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