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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/209144
The synovial and blood monocyte DNA methylomes mirror prognosis, evolution and treatment in early arthritis
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Identifying predictive biomarkers at early stages of early inflammatory arthritis is crucial for starting appropriate therapies to avoid poor outcomes. Monocytes and macrophages, largely associated with arthritis, are contributors and sensors of inflammation through epigenetic modifications. In this study, we investigated associations between clinical features and DNA methylation in blood and synovial fluid (SF) monocytes in a prospective cohort of early inflammatory arthritis patients. Undifferentiated arthritis (UA) blood monocyte DNA methylation profiles exhibited significant alterations in comparison with those from healthy donors. We identified additional differences both in blood and SF monocytes after comparing UA patients grouped by their future outcomes, good versus poor. Patient profiles in subsequent visits revealed a reversion towards a healthy level in both groups, those requiring disease-modifying antirheumatic drugs (DMARDs) and those that remitted spontaneously. Changes in disease activity between visits also impacted DNA methylation, partially concomitant in the SF of UA and in blood monocytes of rheumatoid arthritis patients. Epigenetic similarities between arthritis types allow a common prediction of disease activity. Our results constitute a resource of DNA methylation-based biomarkers of poor prognosis, disease activity and treatment efficacy in early untreated UA patients for the personalized clinical management of early inflammatory arthritis patients.
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CALLE FABREGAT, Carlos de la, RODRIGUEZ UBREVA, J., CIUDAD, L., RAMÍREZ, J., CELIS, R., AZUAGA, A. b., CUERVO, A., GRAELL, E., PÉREZ GARCIA, Carolina, DIAZ TORNE, C., SALVADOR, G., GOMEZ PUERTA, J. a., HARO, I., SANMARTÍ SALA, Raimon, CANETE, J. d., BALLESTAR TARÍN, Esteban. The synovial and blood monocyte DNA methylomes mirror prognosis, evolution and treatment in early arthritis. _Jci Insight_. 2022. Vol. 7, núm. 9, pàgs. e158783-NA. [consulta: 15 de gener de 2026]. ISSN: 2379-3708. [Disponible a: https://hdl.handle.net/2445/209144]