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Smell-taste dysfunctions in extreme weight/eating conditions: analysis of hormonal and psychological interactions

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(1) The objective of this study is to analyze differences in smell-taste capacity between females in extreme weight/eating conditions (EWC) and (2) to explore the interaction between smell/taste capacity, gastric hormones, eating behavior and body mass index (BMI). The sample comprised 239 females in EWC [64 Anorexia nervosa (AN) and 80 age-matched healthy-weight controls, and 59 obese and 36 age-matched healthy-weight controls]. Smell and taste assessments were performed through 'Sniffin' Sticks' and 'Taste Strips,' respectively. The assessment measures included the eating disorders inventory-2, the symptom check list 90-revised, and The Dutch Eating Behavior Questionnaire, as well as peptides from the gastrointestinal tract [Ghrelin, peptide YY, cholecystokinin]. Smell capacity was differentially associated across EWC groups. Smell was clearly impaired in obese participants and increased in AN (hyposmia in Obesity was 54.3 and 6.4 % in AN), but taste capacity did not vary across EWC. Ghrelin levels were significantly decreased in obese subjects and were related to smell impairment. EWC individuals showed a distinct smell profile and circulating ghrelin levels compared to controls. Smell capacity and ghrelin may act as moderators of emotional eating and BMI.

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FERNÁNDEZ ARANDA, Fernando, AGÜERA, Zaida, FERNÁNDEZ-GARCÍA, Jose c., GARRIDO-SANCHEZ, Lourdes, TINAHONES, Francisco j., GINER BARTOLOMÉ, Cristina, BAÑOS RIVERA, Rosa maría, BOTELLA ARBONA, Cristina, CEBOLLA, Ausias, DE LA TORRE, Rafael, FERNÁNDEZ-REAL LEMOS, José manuel, ORTEGA GONZÁLEZ, Fco. javier, FRÜHBECK, Gema, GÓMEZ AMBROSI, Javier, GRANERO, Roser, ISLAM, Mohammed anisul, JIMÉNEZ-MURCIA, Susana, TÁRREGA, Salomé, MENCHÓN MAGRIÑÁ, José manuel, FAGUNDO, Ana beatriz, SANCHO, Carolina, ESTIVILL, Xavier, TREASURE, Janet, CASANUEVA, Felipe f.. Smell-taste dysfunctions in extreme weight/eating conditions: analysis of hormonal and psychological interactions. _Endocrinology_. 2016. Vol. 51, núm. 2, pàgs. 256-267. [consulta: 27 de gener de 2026]. ISSN: 0013-7227. [Disponible a: https://hdl.handle.net/2445/198072]

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