Miniatura

Fitxers

658160.pdf (1.04 MB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2015-05-07

Llicència de publicació

cc-by-nc (c) Lens, S. et al., 2015
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/97461

Aplastic anemia and severe pancytopenia during treatment with peg-interferon, ribavirin and telaprevir for chronic hepatitis C

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

http://dx.doi.org/10.3748/wjg.v21.i17.5421

Resum

Telaprevir and Boceprevir are the first direct acting antivirals approved for chronic hepatitis C in combination with peg-interferon alfa and ribavirin. Pancytopenia due to myelotoxicity caused by these drugs may occur, but severe hematological abnormalities or aplastic anemia (AA) have not been described. We collected all cases of severe pancytopenia observed during triple therapy with telaprevir in four Spanish centers since approval of the drug in 2011. Among 142 cirrhotic patients receiving treatment, 7 cases of severe pancytopenia (5%) were identified and three were consistent with the diagnosis of AA. Mean age was 59 years, five patients had compensated cirrhosis and two patients had severe hepatitis C recurrence after liver transplantation. Severe pancytopenia was diagnosed a median of 10 wk after the initiation of therapy. Three patients had pre-treatment hematological abnormalities related to splenomegaly. In six patients, antiviral treatment was interrupted at the onset of hematological abnormalities. Two patients died due to septic complications and one patient due to acute alveolar hemorrhage. The remaining patients recovered. Severe pancytopenia and especially AA, are not rare during triple therapy with telaprevir in patients with advanced liver disease. Close monitoring is imperative in this setting to promptly detect serious hematological disorders and to prevent further complications.

Matèries

Hepatitis C, Medicaments antivírics, Estudi de casos, Terapèutica, Anèmia

Matèries (anglès)

Hepatitis C, Antiviral agents, Case studies, Therapeutics, Anemia

Citació

Col·leccions

Articles publicats en revistes (Medicina)

Citació

LENS GARCÍA, Sabela, CALLEJA PANERO, José luis, CAMPILLO, Ana, CARRION, José a., BROQUETAS, Teresa, PERELLO, Chrostoe, REVILLA, Juan de la, MARIÑO MÉNDEZ, Zoe, LONDOÑO, María carlota, SÁNCHEZ TAPIAS, José m. (josé maría), URBANO ISPIZUA, Álvaro, FORNS, Xavier. Aplastic anemia and severe pancytopenia during treatment with peg-interferon, ribavirin and telaprevir for chronic hepatitis C. _World Journal of Gastroenterology_. 2015. Vol. 21, núm. 17, pàgs. 5421-5427. [consulta: 28 de gener de 2026]. ISSN: 1007-9327. [Disponible a: https://hdl.handle.net/2445/97461]

Exportar metadades

JSON - METS

Compartir registre