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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/224497
Multi-cohort high-dimensional proteomics reveals early risk markers for lymphoid cancer subtypes
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This study aims to investigate the early stages of lymphoid malignancy pathogenesis and identify pre-diagnostic proteomic markers for lymphoma. Using the SomaScan-7K platform, we analyze 6412 unique plasma proteins in a case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, comprising 4565 participants (484 incident lymphoid malignancy cases, median follow-up 9 years). We identify over 500 unique protein-lymphoid malignancy associations. Enriched pathways include viral protein interactions, cytokine signaling, B-cell receptor signaling, and NF-kappa B activation, reflecting key mechanisms in lymphoma pathogenesis. Cross-cohort validation of the top 20 FDR-significant proteins reveals concordant nominal significance for 70%-95% of the associations in the UK Biobank (Olink) and ARIC (SomaScan) studies. Time-stratified analyses reveals that a subset of these protein-lymphoma associations is evident over a decade before diagnosis. These findings highlight the potential of circulating proteomic markers in risk stratification, early diagnosis, and targeted prevention strategies for lymphoid malignancies.
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MARTIJN KOLIJN, P., SMITH-BYRNE, Karl, BURK, Vernon, VIALLON, Vivian, LEE, Matthew a., PAPIER, Keren, WANG, Ziqiao, LANGERAK, Anton w., SPÄTH, Florentin, DIEPSTRA, Arjan, LILL, Christina m., ZAMORA-ROS, Raul, MACCIOTTA, Alessandra, AIZPURUA, Amaia, TUMINO, Rosario, CHATTERJEE, Nilanjan, TRAVIS, Ruth c., GUNTER, Marc j., PLATZ, Elizabeth a., RIBOLI, Elio, MCKAY, James, VERMEULEN, Roel c. h.. Multi-cohort high-dimensional proteomics reveals early risk markers for lymphoid cancer subtypes. _Nature Communications_. 2025. Vol. 16, núm. 9517. [consulta: 10 de gener de 2026]. ISSN: 2041-1723. [Disponible a: https://hdl.handle.net/2445/224497]