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2018-10-23

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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/127705

Coagulation abnormalities following nexoBrid use: a case report

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https://doi.org/10.1093/jbcr/irx044

Resum

Patients with major burn injury undergo a series of pathophysiologic changes that begin with a systemic inflammatory response and coagulation abnormalities, similar to those experienced by patients with sepsis or severe trauma. Coagulation changes in patients with burns are generally characterized by procoagulant abnormalities, but alterations in fibrinolysis and anticoagulation factors have also been observed. Around 40% of patients with major burn show changes on standard coagulation tests, and these have been related to the severity of the lesions, smoke inhalation, and administration of intensive fluid resuscitation therapy. Current surgical techniques for debridement of burn lesions are aggressive and associated with considerable blood loss. A fast-acting selective enzymatic debriding agent based on bromelain has been recently developed. NexoBrid is indicated for removing eschar in adults with deep partial- and full-thickness thermal burns. A potential effect of oral bromelain on hemostasis has been described, but it is uncertain whether NexoBrid application has a clinically relevant impact in this regard. We present the clinical case of a patient with burns who showed a coagulation abnormality shortly after NexoBrid use.

Matèries

Anticoagulants (Medicina), Fibrinòlisi, Hemorràgia, Coagulació sanguínia, Ferides i lesions, Cremades

Matèries (anglès)

Anticoagulants (Medicine), Fibrinolysis, Hemorrhage, Blood coagulation, Wounds and injuries, Burns and scalds

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Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

MARTIN, Nuria, GUILABERT, Patricia, ABARCA, Luis, USUA, Gemma, SERRACANTA, Jordi, COLOMINA SOLER, M. j. (maría josé). Coagulation abnormalities following nexoBrid use: a case report. _Journal of Burn Care & Research_. 2018. Vol. 39, núm. 6, pàgs. 1067-1070. [consulta: 28 de gener de 2026]. ISSN: 1559-047X. [Disponible a: https://hdl.handle.net/2445/127705]

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