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JAHA.122.025885.pdf (1.05 MB)

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2022-12-06

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cc by-nc-nd (c) Spione, Francesco et al., 2023
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/192293

Impact of Diabetes on 10‐Year Outcomes Following ST‐Segment–Elevation Myocardial Infarction: Insights From the EXAMINATION‐EXTEND Trial

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https://doi.org/10.1161/JAHA.122.025885

Resum

BACKGROUND: Long-term outcomes of ST-segment-elevation myocardial infarction in patients with diabetes have been barely investigated. The objective of this analysis from the EXAMINATION-EXTEND (10-Years Follow-Up of the EXAMINATION trial) trial was to compare 10-year outcomes of patients with ST-segment-elevation myocardial infarction with and without diabetes. METHODS AND RESULTS: Of the study population, 258 patients had diabetes and 1240 did not. The primary end point was patient-oriented composite end point of all-cause death, any myocardial infarction, or any revascularization. Secondary end points were the individual components of the primary combined end point, cardiac death, target vessel myocardial infarction, target lesion revascularization, and stent thrombosis. All end points were adjusted for potential confounders. At 10 years, patients with diabetes showed a higher incidence of patient-oriented composite end point compared with those without (46.5% versus 33.0%; adjusted hazard ratio [HR], 1.31 [95% CI, 1.05-1.61]; P=0.016) mainly driven by a higher incidence of any revascularization (24.4% versus 16.6%; adjusted HR, 1.61 [95% CI, 1.19-2.17]; P=0.002). Specifically, patients with diabetes had a higher incidence of any revascularization during the first 5 years of follow-up (20.2% versus 12.8%; adjusted HR, 1.57 [95% CI, 1.13-2.19]; P=0.007) compared with those without diabetes. No statistically significant differences were found with respect to the other end points. CONCLUSIONS: Patients with ST-segment-elevation myocardial infarction who had diabetes had worse clinical outcome at 10 years compared with those without diabetes, mainly driven by a higher incidence of any revascularizations in the first 5 years.

Matèries

Diabetis, Infart de miocardi, Assaigs clínics

Matèries (anglès)

Diabetes, Myocardial infarction, Clinical trials

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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

SPIONE, Francesco, AREVALOS, Victor, GABANI, Rami, ORTEGA PAZ, Luis, GOMEZ LARA, Josep, JIMENEZ DIAZ, Victor, JIMENEZ, Marcelo, JIMÉNEZ QUEVEDO, Pilar, DILETTI, Roberto, PINEDA, Javier, CAMPO, Gianluca, DI SILVESTRO, Antonio, MARISTANY, Jaume, FLORES, Xacobe, OYARZABAL, Loreto, BASTOS FERNANDEZ, Guillermo, IÑIGUEZ, Andrés, SERRA, Antonio, ESCANED, Javier, IELASI, Alfonso, TESPILI, Maurizio, LENZEN, Mattie, GONZALO, Nieves, BORDES, Pascual, TEBALDI, Matteo, BISCAGLIA, Simone, AL‐SHAIBANI, Soheil, ROMAGUERA, Rafael, GOMEZ HOSPITAL, Joan antoni, RODES CABAU, Josep, SERRUYS, P. w., SABATÉ, Manel, BRUGALETTA, Salvatore. Impact of Diabetes on 10‐Year Outcomes Following ST‐Segment–Elevation Myocardial Infarction: Insights From the EXAMINATION‐EXTEND Trial. _Journal of the American Heart Association_. 2022. Vol. 11, núm. 23, pàgs. e025885. [consulta: 23 de gener de 2026]. ISSN: 2047-9980. [Disponible a: https://hdl.handle.net/2445/192293]

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