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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/180671
The prohibitin-binding compound fluorizoline inhibits mitophagy in cancer cells
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Fluorizoline is a prohibitin-binding compound that triggers apoptosis in several cell lines from murine and human origin, as well as in primary cells from hematologic malignancies by inducing the integrated stress response and ER stress. Recently, it was described that PHB (Prohibitin) 1 and 2 are crucial mitophagy receptors involved in mediating the autophagic degradation of mitochondria. We measured mitophagy in HeLa cells expressing Parkin and in A549, a lung cancer cell line that can undergo mitophagy in a Parkin-independent manner, and we demonstrated that both fluorizoline and rocaglamide A, another PHB-binding molecule, inhibit CCCP- and OA-induced mitophagy. Moreover, we demonstrated that PHBs are mediating Parkin-dependent mitophagy. In conclusion, besides being a potent pro-apoptotic compound, we present fluorizoline as a promising new mitophagy modulator that could be used as anticancer agent.
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NÚÑEZ-VÁZQUEZ, Sonia, et al. The prohibitin-binding compound fluorizoline inhibits mitophagy in cancer cells. Oncogenesis. 2021. Vol. 10, num. 64. ISSN 2157-9024. [consulted: 15 of June of 2026]. Available at: https://hdl.handle.net/2445/180671