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681592.pdf (1.13 MB)

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Data de publicació

2018-08-17

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cc-by (c) Moiola, Cristian P. et al., 2018
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/157640

Patient-Derived Xenograft Models for Endometrial Cancer Research

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Recurs relacionat

https://doi.org/10.3390/ijms19082431

Resum

Endometrial cancer (EC) is the most common malignancy of the genital tract among women in developed countries. Recently, a molecular classification of EC has been performed providing a system that, in conjunction with histological observations, reliably improves EC classification and enhances patient management. Patient-derived xenograft models (PDX) represent nowadays a promising tool for translational research, since they closely resemble patient tumour features and retain molecular and histological features. In EC, PDX models have already been used, mainly as an individualized approach to evaluate the efficacy of novel therapies and to identify treatment-response biomarkers; however, their uses in more global or holistic approaches are still missing. As a collaborative effort within the ENITEC network, here we describe one of the most extensive EC PDX cohorts developed from primary tumour and metastasis covering all EC subtypes. Our models are histologically and molecularly characterized and represent an excellent reservoir of EC tumour samples for translational research. This review compiles the information on current methods of EC PDX generation and their utility and provides new perspectives for the exploitation of these valuable tools in order to increase the success ratio for translating results to clinical practice.

Matèries

Càncer d'endometri, Aparell genital femení, Medicina personalitzada

Matèries (anglès)

Endometrial cancer, Female generative organs, Personalized medicine

Citació

Col·leccions

Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citació

MOIOLA, Cristian P., et al. Patient-Derived Xenograft Models for Endometrial Cancer Research. International Journal of Molecular Sciences. 2018. Vol. 19, num. 8, pags. 2431. ISSN 1661-6596. [consulted: 6 of August of 2026]. Available at: https://hdl.handle.net/2445/157640

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