Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Llicència de publicació
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/124410
Human papillomavirus 16 is an aetiological factor of scrotal cancer
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Background: Squamous cell scrotal carcinoma (SCSC) is an infrequent skin cancer associated historically with occupational carcinogens. Human papillomavirus (HPV) DNA has been associated with SCSC but there is no definitive proof of its oncogenic role. Methods: Human papillomavirus-DNA and -E6*I mRNA were analysed in six invasive histologically typed SCSC. LCM-PCR was used to localise HPV DNA to tumour cells. P16(INK4a)and p53 expression were studied by immunohistochemistry. Results: In three warty or basaloid SCSC HPV16-DNA and E6*I-mRNA were detected. LCM-PCR confirmed HPV16 was in p16(INK4a)-positive malignant cells. However, of three usual-type SCSC, all were HPV-negative and two expressed p53 protein but not p16(INK4a). Conclusions: Human papillomavirus 16 was present in tumour cells and oncogenically active in basaloid and warty SCSC, whereas usual SCSC was HPV-negative and showed immunostaining, suggesting p53 mutation. The dual pathways of oncogenesis and relation between histological type of SCSC and HPV are similar to that in penile cancers.
Matèries
Matèries (anglès)
Citació
Citació
GUIMERÀ, Núria, ALEMANY I VILCHES, Laia, HALEC, Gordana, PAWLITA, Michael, WAIN, Gerard vincent, SALAS VAILEN, José santos, AZIKE, Jerome e., JENKINS, David, SANJOSÉ LLONGUERAS, Silvia de, QUINT, Wim, BOSCH, F. xavier. Human papillomavirus 16 is an aetiological factor of scrotal cancer. _British Journal of Cancer_. 2017. Vol. 116, núm. 1218-1222. [consulta: 12 de febrer de 2026]. [Disponible a: https://hdl.handle.net/2445/124410]