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2013-07-02

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cc-by (c) Serrat, Román et al., 2013
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/124677

The non-canonical Wnt/PKC pathway regulates mitochondrial dynamics through degradation of the ARM-like domain-containing protein Alex3

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Recurs relacionat

https://doi.org/10.1371/journal.pone.0067773

Resum

The regulation of mitochondrial dynamics is vital in complex cell types, such as neurons, that transport and localize mitochondria in high energy-demanding cell domains. The Armcx3 gene encodes a mitochondrial-targeted protein (Alex3) that contains several arm-like domains. In a previous study we showed that Alex3 protein regulates mitochondrial aggregation and trafficking. Here we studied the contribution of Wnt proteins to the mitochondrial aggregation and dynamics regulated by Alex3. Overexpression of Alex3 in HEK293 cells caused a marked aggregation of mitochondria, which was attenuated by treatment with several Wnts. We also found that this decrease was caused by Alex3 degradation induced by Wnts. While the Wnt canonical pathway did not alter the pattern of mitochondrial aggregation induced by Alex3, we observed that the Wnt/PKC non-canonical pathway regulated both mitochondrial aggregation and Alex3 protein levels, thereby rendering a mitochondrial phenotype and distribution similar to control patterns. Our data suggest that the Wnt pathway regulates mitochondrial distribution and dynamics through Alex3 protein degradation.

Matèries

Mitocondris, Proteïnes quinases, Fosforilació, Fenotip

Matèries (anglès)

Mitochondria, Protein kinases, Phosphorylation, Phenotype

Citació

Col·leccions

Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)

Citació

SERRAT REÑÉ, Román, et al. The non-canonical Wnt/PKC pathway regulates mitochondrial dynamics through degradation of the ARM-like domain-containing protein Alex3. PLoS One. 2013. Vol. 8, num. 7, pags. 1-13. ISSN 1932-6203. [consulted: 8 of August of 2026]. Available at: https://hdl.handle.net/2445/124677

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