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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/226898
A machine learning-based transcriptomic signature for predicting tumor recurrence after curative resection in T1 colorectal cancer: a retrospective multicenter cohort study (The Tw1CE trial).
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T1 colorectal cancer (T1 CRC) is increasingly treated with curative-intent endoscopic resection, but tumor recurrence remains a critical factor influencing patient prognosis. However there is no validated biomarker exists to reliably predict post-resection recurrence, limiting risk-adapted follow-up and adjuvant therapy decisions. In this multicenter retrospective cohort study across academic centers in Spain, 138 patients with T1 CRC (2023-2025; ClinicalTrials.gov NCT06314971) were enrolled. From FFPE endoscopic specimens, expression of five mRNAs and two miRNAs was quantified by RT-qPCR, and an XGBoost-based transcriptomic panel was developed. Patients were assigned to training and independent testing cohorts by treatment type. The primary outcome was 3-year recurrence-free survival (RFS); secondary outcomes included 5-year RFS and overall survival (OS). The transcriptomic panel demonstrated high predictive performance in both the training (AUROC = 91.7%) and testing (AUROC = 88.2%) cohorts. Patients classified as high-risk by the panel exhibited significantly worse RFS and OS compared with those classified as low-risk (log-rank P < 0.001). Furthermore, integrating lymphatic invasion with the transcriptomic panel into a combined risk stratification model further improved predictive accuracy (AUROC = 94.6%), and decision curve analysis confirmed its superior clinical utility compared to conventional criteria. This study established a validated machine learning-based transcriptomic classifier derived from endoscopic resection specimens that accurately predicts tumor recurrence in patients with T1 CRC. Our findings highlight the potential of this biomarker panel to enable risk-adapted surveillance strategies and guide decisions regarding additional therapy after curative resection.
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NOMA, Takayuki, DACA ALVAREZ, Maria de los angeles, SAN JUAN, Xavier, IBÁÑEZ, Gemma, MUSULÉN, Eva, GOEL, Ajay. A machine learning-based transcriptomic signature for predicting tumor recurrence after curative resection in T1 colorectal cancer: a retrospective multicenter cohort study (The Tw1CE trial).. _International Journal Of Surgery_. 2026. Vol. 1-13. [consulta: 13 de abril de 2026]. ISSN: 1743-9159. [Disponible a: https://hdl.handle.net/2445/226898]