Deciphering the dual role of Sirtuin

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dc.contributor.advisorVaquero García, Alejandro
dc.contributor.authorCastelló García, José Manuel
dc.contributor.otherUniversitat de Barcelona. Facultat de Medicina i Ciències de la Salut
dc.date.accessioned2024-12-13T10:32:49Z
dc.date.available2025-09-27T05:10:12Z
dc.date.issued2024-09-27
dc.description.abstract[eng] OBJECTIVES: Class IV sirtuins are dual sirtuins that possess deacetylation and ADP-ribosylation activities. The main objective of this PhD was to study of sirtuin duality. Specifically, we focused our attention on the ADPRT actovoty, and its interplay with the deacetylation activity, and the contribution of OAADPr in the process. In order to address this purpose, the following objectives have been developed: 1. Characterization of O-Acetyl ADP-ribosylation as a new Post-Translational modification. 2. Study the functional implications that SIRT7 ADPRT and OAADPRT activities. 3. Determine the in vivo contribution of SIRT7 ADPRT/OAADPRT activity in a ADPRT/OAADPRT-defective SIRT7N189Q knock-in mouse model.ca
dc.format.extent208 p.
dc.format.mimetypeapplication/pdf
dc.identifier.tdxhttp://hdl.handle.net/10803/692838
dc.identifier.urihttps://hdl.handle.net/2445/217090
dc.language.isoengca
dc.publisherUniversitat de Barcelona
dc.rights(c) Castelló García, José Manuel, 2024
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceTesis Doctorals - Facultat - Medicina i Ciències de la Salut
dc.subject.classificationCromatina
dc.subject.classificationEnvelliment
dc.subject.classificationEnzimes
dc.subject.otherChromatin
dc.subject.otherAging
dc.subject.otherEnzymes
dc.titleDeciphering the dual role of Sirtuinca
dc.typeinfo:eu-repo/semantics/doctoralThesisca
dc.typeinfo:eu-repo/semantics/publishedVersion

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Tesis Doctorals - Facultat - Medicina i Ciències de la Salut