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Accepted version

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2021-03-01

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cc-by-nc-nd (c) Elsevier B.V., 2021
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/183215

Cognitive heterogeneity in the offspring of patients with schizophrenia or bipolar disorder: a cluster analysis across family risk

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https://doi.org/10.1016/j.jad.2020.12.090

Abstract

Background: Neurocognitive impairment is considered to lie on a continuum of severity across schizophrenia (SZ) and bipolar disorder (BP), possibly reflecting a gradient of neurodevelopmental load. Cluster analyses have identified different levels of impairment across the two disorders, from none to widespread and severe. We for the first time used this approach to examine cognitive function pooling together children and adolescents at familial risk of SZ or BP. Methods: 220 participants, 49 offspring of individuals with schizophrenia (SZO), 90 offspring of individuals with bipolar disorder (BPO) and 81 offspring of healthy control parents (HC), aged 6 to 17 years, underwent a comprehensive clinical and cognitive assessment. Cognitive measures were used to group SZO and BPO using K-means clustering. Cognitive performance within each of the clusters was compared to that of HC and clinical variables were compared between clusters. Results: We identified three cognitive subgroups: a moderate impairment group, a mild impairment group, and a cognitively intact group. Both SZO and BPO were represented in each of the clusters, yet not evenly, with a larger proportion of the SZO in the moderately impaired cluster, but also a subgroup of BPO showing moderate cognitive dysfunction. Limitations: Participants have yet to reach the age of onset for the examined disorders. Conclusions: The findings point to a range of neurodevelopmental loadings across youth at familial risk of both SZ and BP. They have therefore important implications for the stratification of cognitive functioning and the possibility to tailor interventions to individual levels of impairment.

Subject

Trastorn bipolar, Esquizofrènia, Trastorn bipolar en els infants, Factors de risc en les malalties

Subject (English)

Manic-depressive illness in adolescence, Schizophrenia, Manic-depressive illness in children, Risk factors in diseases

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Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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VALLI, Isabel, et al. Cognitive heterogeneity in the offspring of patients with schizophrenia or bipolar disorder: a cluster analysis across family risk. Journal of Affective Disorders. 2021. Vol. 282, num. 752-765. ISSN 0165-0327. [consulted: 11 of June of 2026]. Available at: https://hdl.handle.net/2445/183215

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