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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/185147
Cognitive clusters in first-episode psychosis
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Impairments in a broad range of cognitive domains have been consistently reported in some individuals with first-episode psychosis (FEP). Cognitive deficits can be observed during the prodromal stage. However, the course of cognitive deficits is still unclear. The aim of this study was to identify cognitive subgroups over time and to compare their sociodemographic, clinical and functional profiles. A total of 114 patients with Schizophrenia Spectrum Disorders were included in the present study. We assessed subjects through psychiatric scales and eight neuropsychological tests at baseline and at two-year follow-up visit. We performed the Partition Around Medoids algorithm with all cognitive variables. Furthermore, we performed a logistic regression to identify the predictors related to the different cognitive clusters at follow-up. Two distinct subgroups were found: the first cluster characterized by cognitive impairment and a second cluster had relatively intact cognition in comparison with norms. Up to 54.7% of patients with cognitive deficits at baseline tended to improve during the first two years of treatment. Patients with intact cognition at follow-up had a higher socioeconomic status, later age of onset, lower negative symptoms and a higher cognitive reserve (CR) at baseline. CR and age of onset were the baseline variables that predicted cognitive impairment. This research allows us to obtain a better understanding of the heterogeneous profile of psychotic disorders. Identifying the characteristics of patients who will
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AMORETTI GUADALL, Silvia, RABELO DA PONTE, Francisco diego, ROSA, Adriane ribeiro, MEZQUIDA MATEOS, Gisela, SÁNCHEZ-TORRES, Ana m., FRAGUAS, David, CABRERA LLORCA, Bibiana, LOBO, Antonio, GONZÁLEZ-PINTO, Ana, PINA CAMACHO, Laura, CORRIPIO, Iluminada, VIETA I PASCUAL, Eduard, TORRENT FONT, Carla, SERNA GÓMEZ, Elena de la, BERGÉ, Daniel, BIOQUE ALCÁZAR, Miquel, GARRIGA, Marina, SERRA NAVARRO, Maria, CUESTA, Manuel j., BERNARDO ARROYO, Miquel. Cognitive clusters in first-episode psychosis. _Schizophrenia Research_. 2021. Vol. 237, núm. 31-39. [consulta: 28 de gener de 2026]. ISSN: 0920-9964. [Disponible a: https://hdl.handle.net/2445/185147]