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2018-11-01

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/140360

Purine-related metabolites and their converting enzymes are altered in frontal; parietal; and temporal cortex at early stages of Alzheimer's disease pathology

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https://doi.org/10.1111/bpa.12592

Abstract

Adenosine, hypoxanthine, xanthine, guanosine, and inosine levels were assessed by HPLC, and the activity of related enzymes 5'-nucleotidase (5'-NT), adenosine deaminase (ADA), and purine nucleoside phosphorylase (PNP) measured in frontal (FC), parietal (PC) and temporal (TC) cortices at different stages of disease progression in Alzheimer's disease (AD) and in age-matched controls. Significantly decreased levels of adenosine, guanosine, hypoxanthine, and xanthine, and apparently less inosine, are found in FC from the early stages of AD; PC and TC show an opposing pattern, as adenosine, guanosine, and inosine are significantly increased at least at determinate stages of AD whereas hypoxanthine and xanthine levels remain unaltered. 5'-NT is reduced in membranes and cytosol in FC mainly at early stages but not in PC, and only at advanced stages in cytosol in TC. ADA activity is decreased in AD when considered as a whole but increased at early stages in TC. Finally, PNP activity is increased only in TC at early stages. Purine metabolism alterations occur at early stages of AD independently of neurofibrillary tangles and β-amyloid plaques. Alterations are stage- and regiondependent, the latter showing opposite patterns in FC compared with PC and TC. Adenosine is the most affected of the assessed purines. Key words: Adenosine, Alzheimer's disease, cerebral cortex, purine metabolism.

Subject

Malaltia d'Alzheimer, Enzimologia, Lòbul frontal, Lòbul temporal, Metabolisme, Purines

Subject (English)

Alzheimer's disease, Enzymology, Frontal lobe, Temporal lobe, Metabolism, Purines

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Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Citation

ALONSO-ANDRÉS, Patricia, et al. Purine-related metabolites and their converting enzymes are altered in frontal; parietal; and temporal cortex at early stages of Alzheimer's disease pathology. Brain Pathology. 2018. Vol. 28, num. 6, pags. 933-946. ISSN 1015-6305. [consulted: 16 of August of 2026]. Available at: https://hdl.handle.net/2445/140360

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