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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/99586
Urban Dust Microbiome: Impact on Later Atopy and Wheezing
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INTRODUCTION: Investigations in urban areas have just begun to
explore how the indoor dust microbiome may affect the
pathogenesis of asthma and allery. We aimed to investigate the
early fungal and bacterial microbiome in house dust with
allergic sensitization and wheezing later in childhood. METHODS:
Individual dust samples from 189 homes of the LISAplus birth
cohort study were collected shortly after birth from living room
floors and profiled for fungal and bacterial microbiome. Fungal
and bacterial diversity was assessed with terminal restriction
fragment length polymorphism (tRFLP) and defined by the Simpson
diversity index. Information on wheezing outcomes and
co-variates until the age of 10 years was obtained by parental
questionnaires. Information on specific allergic sensitization
was available at 6 and 10 years. Logistic regression and General
Estimation Equation (GEE) models were used to examine the
relationship between microbial diversity and health outcomes.
RESULTS: Logistic regression analyses revealed a significantly
reduced risk of developing sensitization to aero-allergens at 6
years and ever wheezing until the age of 10 years for exposure
to higher fungal diversity (adjusted Odds Ratio aOR (95%CI):
0.26 (0.10-0.70)), and 0.42 (0.18-0.96), respectively), in
adjusted analyses. The associations were attenuated for the
longitudinal analyses (GEE) until the age of 10 years. There was
no association between higher exposure to bacterial diversity
and the tested health outcomes. CONCLUSION: Higher early
exposure to fungal diversity might help to prevent from
developing sensitization to aero-allergens in early childhood,
but the reasons for attenuated effects in later childhood
require further prospective studies.
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TISCHER, Christina, WEIKL, Fabian, PROBST, Alexander j., STANDL, Marie, HEINRICH, Joachim, PRITSCH, Karin. Urban Dust Microbiome: Impact on Later Atopy and Wheezing. _Environmental Health Perspectives_. 2016. [consulta: 9 de gener de 2026]. ISSN: 0091-6765. [Disponible a: https://hdl.handle.net/2445/99586]