Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3

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dc.contributor.authorPurdue, Mark P.
dc.contributor.authorJohansson, Mattias
dc.contributor.authorZelenika, Diana
dc.contributor.authorToro, Jorge R.
dc.contributor.authorScelo, Ghislaine
dc.contributor.authorMoore, Lee E.
dc.contributor.authorProkhortchouk, Egor
dc.contributor.authorWu, Xifeng
dc.contributor.authorKiemeney, Lambertus A. L. M.
dc.contributor.authorGaborieau, Valérie
dc.contributor.authorJacobs, Kevin B.
dc.contributor.authorZaridze, David
dc.contributor.authorMatveev, Vsevolod
dc.contributor.authorLubinski, Jan
dc.contributor.authorTrubicka, Joanna
dc.contributor.authorSzeszenia-Dabrowska, Neonila
dc.contributor.authorLissowska, Jolanta
dc.contributor.authorRudnai, Peter
dc.contributor.authorFabianova, Eleonora
dc.contributor.authorBucur, Alexandru
dc.contributor.authorBencko, Vladimir
dc.contributor.authorForetova, Lenka
dc.contributor.authorJanout, Vladimir
dc.contributor.authorBoffetta, Paolo
dc.contributor.authorColt, Joanne S.
dc.contributor.authorDavis, Faith G.
dc.contributor.authorSchwartz, Kendra L.
dc.contributor.authorBanks, Rosamonde E.
dc.contributor.authorSelby, Peter J.
dc.contributor.authorHarnden, Patricia
dc.contributor.authorBerg, Christine D.
dc.contributor.authorHsing, Ann W.
dc.contributor.authorGrubb III, Robert L.
dc.contributor.authorBoeing, Heiner
dc.contributor.authorVineis, Paolo
dc.contributor.authorClavel-Chapelon, Françoise
dc.contributor.authorPalli, Domenico
dc.contributor.authorTumino, Rosario
dc.contributor.authorKrogh, Vittorio
dc.contributor.authorPanico, Salvatore
dc.contributor.authorDuell, Eric J.
dc.contributor.authorQuirós, José Ramón
dc.contributor.authorSánchez, María José
dc.contributor.authorNavarro, Carmen
dc.contributor.authorArdanaz, Eva
dc.contributor.authorDorronsoro, Miren
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorAllen, Naomi E.
dc.contributor.authorBueno de Mesquita, H. Bas
dc.contributor.authorPeeters, Petra H. M.
dc.contributor.authorTrichopoulos, Dimitrios
dc.contributor.authorLinseisen, Jakob
dc.contributor.authorLjungberg, Börje
dc.contributor.authorOvervad, Kim
dc.contributor.authorTjønneland, Anne
dc.contributor.authorRomieu, Isabelle
dc.contributor.authorRiboli, Elio
dc.contributor.authorMukeriya, Anush
dc.contributor.authorShangina, Oxana
dc.contributor.authorStevens, Victoria L.
dc.contributor.authorThun, Michael J.
dc.contributor.authorDiver, W. Ryan
dc.contributor.authorGapstur, Susan M.
dc.contributor.authorPharoah, Paul D. P.
dc.contributor.authorEaston, Douglas F.
dc.contributor.authorAlbanes, Demetrius
dc.contributor.authorWeinstein, Stephanie J.
dc.contributor.authorVirtamo, Jarmo
dc.contributor.authorVatten, Lars
dc.contributor.authorHveem, Kristian
dc.contributor.authorNjølstad, Inger
dc.contributor.authorTell, Grethe
dc.contributor.authorStoltenberg, Camilla
dc.contributor.authorKumar, Rajiv
dc.contributor.authorKoppova, Kvetoslava
dc.contributor.authorCussenot, Olivier
dc.contributor.authorBenhamou, Simone
dc.contributor.authorOosterwijk, Egbert
dc.contributor.authorVermeulen, Sita H.
dc.contributor.authorAben, Katja K.
dc.contributor.authorVan der Marel, Saskia L.
dc.contributor.authorYe, Yuanqing
dc.contributor.authorWood, Christopher G.
dc.contributor.authorPu, Xia
dc.contributor.authorMazur, Alexander M.
dc.contributor.authorBoulygina, Eugenia S.
dc.contributor.authorChekanov, Nikolai N.
dc.contributor.authorFoglio, Mario
dc.contributor.authorLechner, Doris
dc.contributor.authorGut, Ivo G.
dc.contributor.authorHeath, Simon C.
dc.contributor.authorBlanche, Hélène
dc.contributor.authorHutchinson, Amy
dc.contributor.authorThomas, Gilles
dc.contributor.authorWang, Zhaoming
dc.contributor.authorYeager, Meredith
dc.contributor.authorFraumeni, Joseph F.
dc.contributor.authorSkryabin, Konstantin G.
dc.contributor.authorMcKay, James D.
dc.contributor.authorRothman, Nathaniel
dc.contributor.authorChanock, Stephen J.
dc.contributor.authorLathrop, Mark
dc.contributor.authorBrennan, Paul
dc.contributor.authorChow, Wong-Ho
dc.date.accessioned2018-12-07T11:40:40Z
dc.date.available2018-12-07T11:40:40Z
dc.date.issued2011-01
dc.date.updated2018-07-24T13:02:26Z
dc.description.abstractWe conducted a two-stage genome-wide association study of renal cell carcinoma (RCC) in 3,772 affected individuals (cases) and 8,505 controls of European background from 11 studies and followed up 6 SNPs in 3 replication studies of 2,198 cases and 4,918 controls. Two loci on the regions of 2p21 and 11q13.3 were associated with RCC susceptibility below genome-wide significance. Two correlated variants (r(2) = 0.99 in controls), rs11894252 (P = 1.8 x 10(-8)) and rs7579899 (P = 2.3 x 10(-9)), map to EPAS1 on 2p21, which encodes hypoxia-inducible-factor-2 alpha, a transcription factor previously implicated in RCC. The second locus, rs7105934, at 11q13.3, contains no characterized genes (P = 7.8 x 10(-14)). In addition, we observed a promising association on 12q24.31 for rs4765623, which maps to SCARB1, the scavenger receptor class B, member 1 gene (P = 2.6 x 10(-8)). Our study reports previously unidentified genomic regions associated with RCC risk that may lead to new etiological insights.
dc.format.extent11 p.
dc.format.mimetypeapplication/pdf
dc.identifier.pmid21131975
dc.identifier.urihttps://hdl.handle.net/2445/126785
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1038/ng.723
dc.relation.ispartofNature Genetics, 2011, vol. 43, num. 1, p. 60-65
dc.relation.urihttps://doi.org/10.1038/ng.723
dc.rights(c) Purdue et al., 2011
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.sourceArticles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
dc.subject.classificationCàncer de ronyó
dc.subject.classificationGenòmica
dc.subject.otherKidney cancer
dc.subject.otherGenomics
dc.titleGenome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/acceptedVersion

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