Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Tots els drets reservats
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/68688
Neurological soft signs in obsessive-compulsive disorder: two empirical studies and meta-analysis
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Neurological soft signs (NSS) have been inconsistently reported in obsessive-compulsive disorder (OCD) but may make an impact on treatment response. Method: The current study examined the presence of NSS in two independent European samples of OCD patients (combined 85 patients and 88 matched healthy controls) using a standardized instrument and conducted a meta-analysis of all published studies identified in the literature with the aim to provide a more definitive answer to the question of whether OCD patients are characterized by increased NSS. Results Both empirical studies found elevated NSS scores in patients compared with matched controls. The results of the meta-analysis, which included 15 studies (combined 498 patients and 520 controls) showed large effect sizes (Hedges' g=1.27, 95% confidence interval 0.80-1.75), indicating that OCD patients have significantly higher rates of NSS than matched controls on both sides of the body and in multiple domains (motor coordination, sensory integration and primitive reflexes). The results were robust and remained largely unchanged in our reliability analyses, which controlled for possible outliers. Meta-regression was employed to examine the role of potential variables of interest including sociodemographic variables, symptom severity, medication effects and the use of different instruments, but none of these variables was clearly associated with NSS. Conclusions: As a group, OCD patients are characterized by increased rates of NSS, compared with healthy controls. However, their origins and potential clinical importance remain to be clarified. Future directions for research are discussed.
Citació
Citació
JAAFARI, Nemat, FERNÁNDEZ DE LA CRUZ, Lorena, GRAU, M., KNOWLES, E., RADUA, Joaquim, WOODERSON, S., SEGALÀS COSI, Cinto, ALONSO ORTEGA, María del pino, PHILLIPS, M. l., MENCHÓN MAGRIÑÁ, José manuel, MATAIX-COLS, David. Neurological soft signs in obsessive-compulsive disorder: two empirical studies and meta-analysis. _Psychological Medicine_. 2013. Vol. 43, núm. 5, pàgs. 1069-1079. [consulta: 20 de gener de 2026]. ISSN: 0033-2917. [Disponible a: https://hdl.handle.net/2445/68688]