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2015-10-19

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cc-by (c) Arriarán, Sofía et al., 2015
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/69734

The urea cycle of rat white adipose tissue

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http://dx.doi.org/10.1039/c5ra16398f

Abstract

White adipose tissue (WAT) contains a powerful metabolic machinery related to energy metabolism and partition. The adaptive, regulatory, size and structural variety of WAT agrees with this control role. However, its nitrogen metabolism has been sparsely studied and we know close to nothing about its implication on N-related processes and homoeostasis. We have studied, and found a complete urea cycle (liver type) in four WAT sites (gene expressions and enzyme activities). We postulated a possible function of the cycle (under basal conditions) in the control of arginine handling through citrulline synthesis. In our opinion, the metabolic and control potential of WAT on energy metabolism is second only to liver. This impression should be extended to amino acid metabolism too, WAT providing an extra-intestinal source of citrulline to maintain the body availability of arginine independently of the operation of intestine-liver urea cycle for N disposal.

Subject

Urea, Teixit adipós, Glucòlisi, Aminoàcids, Rates (Animals de laboratori)

Subject (English)

Urea, Adipose tissues, Glycolysis, Amino acids, Rats as laboratory animals

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Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
Articles publicats en revistes (Institut de Biomedicina (IBUB))

Citation

ARRIARÁN, Sofía, et al. The urea cycle of rat white adipose tissue. RSC Advances. 2015. Vol. 5, num. 113, pags. 93403-93414. ISSN 2046-2069. [consulted: 18 of August of 2026]. Available at: https://hdl.handle.net/2445/69734

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