Carregant...
Fitxers
Tipus de document
ArticleVersió
Versió publicadaData de publicació
Tots els drets reservats
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/50283
Characterization of human pancreatic orthotopic tumor xenografts suitable for drug screening
Títol de la revista
Director/Tutor
ISSN de la revista
Títol del volum
Recurs relacionat
Resum
Background Efforts to identify novel therapeutic options for human pancreatic ductal adenocarcinoma (PDAC) have failed to result in a clear improvement in patient survival to date. Pancreatic cancer requires efficient therapies that must be designed and assayed in preclinical models with improved predictor ability. Among the available preclinical models, the orthotopic approach fits with this expectation, but its use is still occasional. Methods An in vivo platform of 11 orthotopic tumor xenografts has been generated by direct implantation of fresh surgical material. In addition, a frozen tumorgraft bank has been created, ensuring future model recovery and tumor tissue availability. Results Tissue microarray studies allow showing a high degree of original histology preservation and maintenance of protein expression patterns through passages. The models display stable growth kinetics and characteristic metastatic behavior. Moreover, the molecular diversity may facilitate the identification of tumor subtypes and comparison of drug responses that complement or confirm information obtained with other preclinical models. Conclusions This panel represents a useful preclinical tool for testing new agents and treatment protocols and for further exploration of the biological basis of drug responses.
Matèries
Matèries (anglès)
Citació
Citació
PÉREZ TORRAS, Sandra, VIDAL PLA, Anna, MIQUEL MORERA, Rosa, ALMENDRO NAVARRO, Vanessa, FERNÁNDEZ-CRUZ, Laureano, NAVARRO COLÁS, Salvador, MAUREL SANTASUSANA, Joan, CARBÓ CARBÓ, Neus, GASCÓN, Pere, MAZO SÁNCHEZ, Adela. Characterization of human pancreatic orthotopic tumor xenografts suitable for drug screening. _Analytical Cellular Pathology / Cellular Oncology_. 2011. Vol. 34, núm. 6, pàgs. 511-521. [consulta: 24 de gener de 2026]. ISSN: 1570-5870. [Disponible a: https://hdl.handle.net/2445/50283]