Miniatura

Fitxers

881848.pdf (178.3 KB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2024-03-06

Tots els drets reservats

Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/218737

MOG Antibodies Restricted to CSF in Children With Inflammatory CNS Disorders

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

https://doi.org/10.1212/WNL.0000000000209199

Resum

Objectives To assess the clinical significance of myelin oligodendrocyte glycoprotein antibodies (MOG-abs) restricted to CSF in children with inflammatory CNS disorders. Methods Patients included 760 children (younger than 18 years) from 3 multicenter prospective cohort studies: (A) acquired demyelinating syndromes, including acute disseminated encephalomy- elitis (ADEM); (B) non-ADEM encephalitis; and (C) noninflammatory neurologic disorders. For all cases, paired serum/CSF samples were systematically examined using brain immuno- histochemistry and live cell-based assays. Results A total of 109 patients (14%) had MOG-abs in serum or CSF: 79 from cohort A, 30 from B, and none from C. Of these, 63 (58%) had antibodies in both samples, 37 (34%) only in serum, and 9 (8%) only in CSF. Children with MOG-abs only in CSF were older than those with MOG-abs only in serum or in both samples (median 12 vs 6 vs 5 years, p = 0.0002) and were more likely to have CSF oligoclonal bands (86% vs 12% vs 7%, p = 0.0001) and be diagnosed with multiple sclerosis (6/9 [67%] vs 0/37 [0%] vs 1/63 [2%], p < 0.0001). Discussion Detection of MOG-abs in serum or CSF is associated with CNS inflammatory disorders. Children with MOG-abs restricted to CSF are more likely to have CSF oligoclonal bands and multiple sclerosis than those with MOG-abs detectable in serum.

Matèries

Malalties del sistema nerviós central, Glicoproteïnes, Malalties dels infants

Matèries (anglès)

Central nervous system diseases, Glycoproteins, Children's diseases

Citació

Col·leccions

Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citació

OLIVÉ CIRERA, Gemma, BRUIJSTENS, Arlette l., FONSECA, Elianet g., CHEN, Li-wen, CABALLERO, Eva, MARTINEZ HERNANDEZ, Eugenia, GUASP, Mar, SEPÚLVEDA, María, NARANJO, Laura, RUIZ GARCÍA, Raquel, BLANCO MORGADO, Yolanda, SAIZ, Albert, DALMAU OBRADOR, Josep, ARMANGUÉ, Thaís. MOG Antibodies Restricted to CSF in Children With Inflammatory CNS Disorders. _Neurology_. 2024. Vol. 102, núm. 7. [consulta: 21 de gener de 2026]. ISSN: 0028-3878. [Disponible a: https://hdl.handle.net/2445/218737]

Exportar metadades

JSON - METS

Compartir registre