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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/180372
Adverse prognostic impact of complex karyotype (≥3 cytogenetic alterations) in adult T-cell acute lymphoblastic leukemia (T-ALL)
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The potential prognostic value of conventional karyotyping in adult T-cell acute lymphoblastic leukemia (T-ALL) remains an open question. We hypothesized that a modified cytogenetic classification, based on the number and type of cytogenetic abnormalities, would allow the identification of high-risk adult T-ALL patients. Complex karyotype defined by the presence of ≥3 cytogenetic alterations identified T-ALL patients with poor prognosis in this study. Karyotypes with ≥3 abnormalities accounted for 16 % (22/139) of all evaluable karyotypes, corresponding to the largest poor prognosis cytogenetic subgroup of T-ALL identified so far. Patients carrying karyotypes with ≥3 cytogenetic alterations showed a significantly inferior response to therapy, and a poor outcome in terms of event-free survival (EFS), overall survival (OS) and cumulative incidence of relapse (CIR), independently of other baseline characteristics and the end-induction minimal residual disease (MRD) level. Additional molecular analyses of patients carrying ≥3 cytogenetic alterations showed a unique molecular profile that could contribute to understand the underlying molecular mechanisms of resistance and to evaluate novel targeted therapies (e.g. IL7R directed) with potential impact on outcome of adult T-ALL patients.
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GENESCÀ, Eulàlia, MORGADES, Mireia, GONZÁLEZ GIL, Celia, FUSTER TORMO, Francisco, HAFERLACH, Claudia, MEGGENDORFER, Manja, MONTESINOS, Pau, BARBA, Pere, GIL, Cristina, COLL, Rosa, MORENO, María josé, MARTÍNEZ CARBALLEIRA, Daniel, GARCÍA CADENAS, Irene, VIVES, Susana, RIBERA, Jordi, GONZÁLEZ CAMPOS, José, DÍAZ BEYÀ, Marina, MERCADAL, Santiago, ARTOLA, María teresa, CLADERA, Antonia, TORMO, Mar, BERMÚDEZ, Arancha, VALL LLOVERA, Ferran, MARTÍNEZ SÁNCHEZ, Pilar, AMIGO, María luz, MONSALVO, Silvia, NOVO, Andrés, CERVERA, Marta, GARCÍA GUIÑON, Antonio, CIUDAD, Juana, CERVERA, José, HERNÁNDEZ RIVAS, Jesús maría, GRANADA, Isabel, HAFERLACH, Torsten, ORFAO, Alberto, SOLÉ, Francesc, RIBERA, Josep maria. Adverse prognostic impact of complex karyotype (≥3 cytogenetic alterations) in adult T-cell acute lymphoblastic leukemia (T-ALL). _Leukemia Research_. 2021. Vol. 109, núm. 106612. [consulta: 20 de gener de 2026]. ISSN: 0145-2126. [Disponible a: https://hdl.handle.net/2445/180372]